Early Risk Assessment in Household Contacts (≥10 Years) of TB Patients by New Diagnostic Tests in 3 African Countries

Active, not recruitingOBSERVATIONAL
Enrollment

2,100

Participants

Timeline

Start Date

March 1, 2021

Primary Completion Date

April 30, 2024

Study Completion Date

April 30, 2024

Conditions
Tuberculosis
Interventions
DIAGNOSTIC_TEST

New test candidates

"The following new diagnostic tests will be done after the completion of the study with the samples (blood, sputum, urine) and data (digital X-ray) obtained during the study period:~CAD4TB / qXR Xpert Ultra® FLOW-TB TAM-TB 4RISK and COR Cepheid 3-gene signature cartridge BioMérieux ISIT TB blood transcription signature assay Multiplex LSHTM in-house host biomarker assay TB Screen biosignature SeroSelect~Retrospective testing of participants' samples and data acquired during the study period, differentiated between participants with co-prevalent/incipient TB and participants staying health throughout the trial"

Trial Locations (3)

Unknown

Instituto Nacional de Saúde (INS) Centro de Investigação e Treino em Saúde da Polana Caniço, Maputo

NIMR - Mbeya Medical Research Centre, Mbeya

Biomedical Research & Training Institute (BRTI), Harare

All Listed Sponsors
collaborator

European and Developing Countries Clinical Trials Partnership (EDCTP)

OTHER_GOV

lead

Michael Hoelscher

OTHER

NCT04781257 - Early Risk Assessment in Household Contacts (≥10 Years) of TB Patients by New Diagnostic Tests in 3 African Countries | Biotech Hunter | Biotech Hunter