Pegloticase and Methotrexate Co-administered in Participants With Uncontrolled Gout Who Previously Failed Pegloticase Monotherapy

PHASE4CompletedINTERVENTIONAL
Enrollment

11

Participants

Timeline

Start Date

March 8, 2021

Primary Completion Date

August 23, 2022

Study Completion Date

April 24, 2023

Conditions
Uncontrolled Gout
Interventions
BIOLOGICAL

Pegloticase

Participants will receive pegloticase with MTX for up to 24 weeks during the treatment period. Participants may opt to receive pegloticase with MTX for an additional 24 weeks.

DRUG

Methotrexate (MTX)

Participants will receive MTX during the run-in period then pegloticase with MTX for up to 24 weeks during the treatment period. Participants may opt to receive pegloticase with MTX for an additional 24 weeks.

Trial Locations (15)

16635

Altoona Center for Clinical Research, Duncansville

20902

The Center for Rheumatology and Bone Research, Wheaton

33046

Napa Research, Pompano Beach

33063

Life Clinical Trials, Margate

33324

IRIS Research and Development, LLC, Plantation

33609

GCP Clinical Research, LLC, Tampa

77043

Biopharma Informatic, LLC, Houston

85210

Arizona Arthritis and Rheumatology Associates, Mesa

85306

Arizona Arthritis and Rheumatology Associates, Glendale

86001

Arizona Arthritis and Rheumatology Associates, Flagstaff

90404

Providence St. John's Health Clinic, Santa Monica

94578

East Bay Rheumatology Medical Group, San Leandro

98021

Western Washington Arthritis Clinic, Bothell

35294-0002

University of Alabama at Birmingham (UAB) - Center for Education & Research on Therapeutics of Musculoskeletal Disorders, Birmingham

80045-2536

University of Colorado Anschutz Medical Campus, Aurora

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Amgen

INDUSTRY