557
Participants
Start Date
April 26, 2021
Primary Completion Date
September 26, 2025
Study Completion Date
October 17, 2025
Atezolizumab
Atezolizumab will be administered by intravenous (IV) infusion at a fixed dose of 1200 mg on Day 1 of each 21-day cycle until unacceptable toxicity or loss of clinical benefit as determined by the investigator.
Lenvatinib
Lenvatinib will be administered once daily by mouth each day of every 21-day study treatment cycle. Participants with a baseline body weight of \< 60 kg will receive a daily dose of 8 mg. Participants with a baseline body weight of ≥ 60 kg will receive a daily dose of 12 mg.
Sorafenib
Sorafenib will be administered at a dose of 800 mg per day, i.e. two tablets of 200 mg swallowed by mouth twice daily (equivalent to a total daily dose of 800 mg) each day of every 21-day study treatment cycle.
Chi-Mei Medical Centre, Tainan City
University Medical Center Ljubljana, Ljubljana
Hospital Erasme, Brussels
Klinik Favoriten, Vienna
Cliniques Universitaires St-Luc, Brussels
Makati Medical Center, Makati City
The Medical City, Pasig
AZ KLINA, Brasschaat
UZ Leuven, Leuven
Inselspital Bern Medizin Gastroenterologie, Bern
Universitätsklinikum St. Pölten, Sankt Pölten
Complex Oncological Center - Plovdiv, EOOD, Plovdiv
Multiprofile Hospital for Active Treatment Uni Hospital, Panagyurishte
Uniklinikum Salzburg, LKH, Salzburg
Cebu Doctors' University Hospital, Cebu City
Medizinische Universität Innsbruck, Innsbruck
Universitätsspital Zürich Medizin Gastroenterologie, Zurich
AZ Delta (Campus Rumbeke), Roeselare
Clinical Hospital Centre Zagreb, Zagreb
National Taiwan University Hospital, Zhongzheng Dist.
Clinica CIMCA, San José
ICIMED Instituto de Investigación en Ciencias Médicas, San José
Azienda Ospedaliera Ordine Mauriziano di Torino, Turin
Chulalongkorn Hospital, Bangkok
National Cancer Center, Goyang-si
Faculty of Med. Siriraj Hosp., Bangkok
AirForce Specialized Hospital, Cairo
Anhui Province Cancer Hospital, Hefei
APHM, Marseille
North Estonia Medical Centre, Oncology and hematology Clinic, Tallinn
CHA Bundang Medical Center, Gyeonggi-do
Hospital Universitario Reina Sofia, Córdoba
Agioi Anargiroi Hospital of Kifissia, Nea Kifissia
Complejo Hospitalario Universitario de Santiago (CHUS), Santiago de Compostela
Uludag Uni Hospital, Bursa
Fondazione IRCCS Ospedale Maggiore Policlinico, Milan
Hospital General Universitario Gregorio Marañon, Madrid
Clinica Universidad de Navarra Madrid, Madrid
START Madrid. Centro Integral Oncologico Clara Campal, Madrid
Med. Hochschule Hannover, Hanover
Clinica Universitaria de Navarra, Pamplona/iruña
CHU de Toulouse - Hôpital Rangueil, Toulouse
TAYS Radius rakennus, Tampere
CHU Bordeaux, Pessac
Bakirkoy Dr. Sadi Konuk Egitim ve Arastirma Hastanesi, Tibbi Onkoloji, Bakirkoy / Istanbul
Medipol Mega Üniversite Hastanesi Göztepe, Ba?c?lar
CH Saint Eloi, Montpellier
Centre Eugene Marquis;Service d'oncologie, Rennes
Ege Uni Medical Faculty Hospital, Izmir
IRCCS Istituto Oncologico Veneto (IOV), Padua
CHU Grenoble Sud, Grenoble
A.O. S. Orsola Malpighi, Bologna
CHU de Nantes - Hotel Dieu, Nantes
Hospital Universitario la Fe, Valencia
Hospital Universitario Miguel Servet, Zaragoza
Azienda Ospedaliero-Universitaria Careggi, Florence
Tartu University Hospital, Tartu
Hopitaux de Brabois - Gastro-Entereologie, Vandœuvre-lès-Nancy
Uniklinik Mainz, Mainz
Azlenda Ospendaliero-Universitaria Pisana, Pisa
CHRU de Lille - Hopital Claude Huriez, Lille
Uni Malaya Medical Center, Kuala Lumpur
Klinik Johann Wolfgang von Goethe Uni, Frankfurt
Institute Kanser Negara (IKN), Putrajaya
Universität Tübingen, Tübingen
APHP - Hopital Saint Antoine, Paris
Fondazione Pascale, Napoli
Azienda Osp Uni Seconda Università Degli Studi Di Napoli, Napoli
Ospedale del Mare, Napoli
Universitätsklinikum Ulm, Ulm
A.O.U. Policlinico Paolo Giaccone, Palermo
Hopital Paul Brousse, Villejuif
Shengjing Hospital of China Medical University, Shenyang
"FSBI National Medical Research Center of Oncology N.N. Blokhin?", Moscow
I.M.Sechenov First Moscow State Medical University (1st MSMU), Moskva
Moscow City Oncology Hospital #62, Moscow
Zhongshan Hospital Fudan University, Shanghai
Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai
Jiangsu Province Hospital (the First Affiliated Hospital With Nanjing Medical University), Nanjing
Tianjin Cancer Hospital, Tianjin
Fujian Provincial Hospital, Fuzhou
Hunan Cancer Hospital, Changsha
The First Affiliated Hospital, Sun Yat-sen University, Guangzhou
Nanfang Hospital, Southern Medical University, Guangzhou
Rambam Health Care Campus, Haifa
Rabin Medical Center, Petah Tikva
Sourasky Medical Center, Tel Aviv
Hospital Felicio Rocho, Belo Horizonte
Hospital Moinhos de Vento, Porto Alegre
Hospital Sao Lucas - PUCRS, Porto Alegre
Centro de Pesquisa e Ensino em Oncologia de Santa Catarina - CEPEN, Florianópolis
Clinicas Oncologicas Integradas - COI, Rio de Janeiro
Beneficencia Portuguesa de Sao Paulo, São Paulo
Arthur J.E. Child Comprehensive Cancer Center-Calgary, Calgary
Cross Cancer Institute, Edmonton
Juravinski Cancer Centre, Hamilton
Princess Margaret Cancer Center, Toronto
Laiko General Hospital Athen, Athens
Azienda Ospedaliera San Camillo Forlanini, Rome
Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome
Fujita Health University Hospital, Aichi
National Cancer Center Hospital East, Chiba
Kurume University Hospital, Fukuoka
Hiroshima University Hospital, Hiroshima
Japanese Red Cross Society Himeji Hospital, Hyōgo
Yokohama City University Medical Center, Kanagawa
The University of Osaka Hospital, Osaka
Kindai University Hospital, Osaka
Jichi Medical University Hospital, Tochigi
Japanese Red Cross Musashino Hospital, Tokyo
Samsung Medical Center, Seoul
Severance Hospital, Yonsei University Health System, Seoul
Hospital Son Llatzer, Palma de Mallorca
Memorial Ankara Hastanesi, Ankara
Ac?badem Altunizade Hastanesi, Istanbul
Hacettepe Uni Medical Faculty Hospital, Sihhiye/Ankara
The Clatterbridge Cancer Centre NHS Foundation Trust, Liverpool
Royal Free Hospital, London
King College Hospital NHS Foundation Trust, London
Hammersmith Hospital, London
Christie Hospital Nhs Trust, Manchester
Freeman Hospital, Newcastle upon Tyne
Churchill Hospital, Oxford
Hoffmann-La Roche
INDUSTRY