LVAD Versus GDMT in Ambulatory Advanced Heart Failure Patients

NARecruitingINTERVENTIONAL
Enrollment

92

Participants

Timeline

Start Date

February 24, 2021

Primary Completion Date

February 28, 2029

Study Completion Date

February 28, 2029

Conditions
End-stage Heart Failure
Interventions
DEVICE

HeartMate 3 TM Left Ventricular Assist System

The HeartMate 3 TM Left Ventricular Assist System will be implanted within 21 days of randomization.

OTHER

Guideline Directed Medical Therapy

Patients randomized in the control group will continue their guideline directed medical therapy which comprises the following stable combination at the maximal tolerated dose of betablockers, Angiotensin-Converting-Enzyme-inhibitors or Angiotensin II Receptor Blockers or Angiotensin receptor Neprilysin inhibitor and Mineralocorticoid Receptor Antagonists and Sodium-GLucose co-Transporter-2 (SGLT2) inhibitors if tolerated.

Trial Locations (8)

Unknown

RECRUITING

CHU Besançon, Besançon

RECRUITING

Hôpital Pneumologique et Cardiovasculaire Louis Pradel, Bron

RECRUITING

CHU Caen, Caen

RECRUITING

La Tronche Hospital / CHU Grenoble, La Tronche

RECRUITING

Arnaud de Villeneuve Hospital / CHU Montpellier, Montpellier

RECRUITING

CHU Rouen, Rouen

RECRUITING

CHU Tours, Tours

RECRUITING

CHRU, Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu, Vandœuvre-lès-Nancy

All Listed Sponsors
lead

Hospices Civils de Lyon

OTHER