Durvalumab and Chemotherapy Induction Followed by Durvalumab and Radiotherapy in Large Volume Stage III NSCLC

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

10

Participants

Timeline

Start Date

September 24, 2021

Primary Completion Date

June 30, 2026

Study Completion Date

June 30, 2026

Conditions
Non-small Cell Lung Cancer Stage III
Interventions
COMBINATION_PRODUCT

durvalumab plus platinum-based chemotherapy (cisplatin or carboplatin plus vinorelbine or pemetrexed)

Induction therapy: durvalumab plus histology-based chemotherapy regimen (cisplatin or carboplatin plus vinorelbine for squamous histology and pemetrexed for non-squamous histology).

COMBINATION_PRODUCT

Durvalumab plus radiotherapy

Concomitant durvalumab and radiotherapy

BIOLOGICAL

durvalumab

Consolidation treatment with durvalumab

Trial Locations (3)

20133

Fondazione IRCCS Istituto Nazionale dei Tumori, Milan

Unknown

Gustave Roussy Institute, Paris

Vall d'Hebron Barcelona Hospital, Barcelona

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

collaborator

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

OTHER

lead

Mario Negri Institute for Pharmacological Research

OTHER