Comparison of Landiolol Versus Standard of Care for Prevention of Mortality in Patients Hospitalized for a Septic Shock With Hypercontractility

PHASE3RecruitingINTERVENTIONAL
Enrollment

360

Participants

Timeline

Start Date

February 1, 2021

Primary Completion Date

June 30, 2027

Study Completion Date

September 30, 2027

Conditions
Septic ShockTachycardiaMortality During Septic ShockBeta-blocker
Interventions
OTHER

echocardiography

Full echocardiography will be performed at baseline and during the follow-up at H1, H3, H6 and H12.

DRUG

Landiolol

Patients randomized to the experimental group will be treated according to the standard of care plus for 2 days with landiolol IV started at a dose of 1 microgram/kg/min and progressively increased every 10 minutes to a maximum of 40 micrograms/kg/min.

Trial Locations (1)

80480

RECRUITING

CHU Amiens, Amiens

All Listed Sponsors
collaborator

CH Dieppe

UNKNOWN

collaborator

CH Elbeuf

UNKNOWN

collaborator

CH Le Havre

UNKNOWN

collaborator

Centre Hospitalier de Beauvais

OTHER

collaborator

CH Compiègne

UNKNOWN

collaborator

CH Laon

UNKNOWN

collaborator

University Hospital, Caen

OTHER

collaborator

CH Cherbourg

UNKNOWN

collaborator

University Hospital, Lille

OTHER

collaborator

CH Douai

UNKNOWN

collaborator

CH Montreuil

UNKNOWN

collaborator

Centre Hospitalier de Roubaix

OTHER

collaborator

Centre Hospitalier de Bethune

NETWORK

collaborator

CH Lomme

UNKNOWN

collaborator

Centre Hospitalier de Lens

OTHER

collaborator

Tourcoing Hospital

OTHER

collaborator

Centre Hospitalier VALENCIENNES

OTHER

collaborator

Centre Hospitalier Arras

OTHER

collaborator

Hospital Ambroise Paré Paris

OTHER

collaborator

University Hospital, Brest

OTHER

collaborator

Henri Mondor University Hospital

OTHER

collaborator

Hospital Avicenne

OTHER

collaborator

University Hospital, Montpellier

OTHER

collaborator

CH Calais

UNKNOWN

collaborator

Hôpital Edouard Herriot

OTHER

collaborator

Centre Hospitalier Universitaire de Nīmes

OTHER

collaborator

Groupe Hospitalier Pitié-Salpêtrière

UNKNOWN

collaborator

Hôpital Louis Mourier, Colombes

UNKNOWN

lead

Centre Hospitalier Universitaire, Amiens

OTHER