Different Immunosuppressive Treatment in iMN

PHASE3RecruitingINTERVENTIONAL
Enrollment

200

Participants

Timeline

Start Date

April 14, 2021

Primary Completion Date

March 31, 2025

Study Completion Date

March 31, 2027

Conditions
Idiopathic Membranous Nephropathy
Interventions
DRUG

Prednisone

1mg/kg/d p.o.which will be tapered after 2 months and discontinued over a 6-12 month period.

DRUG

Cyclophosphamide

1-2mg/kg/d p.o. with a target accumulated dose of 12g.

DRUG

Rituximab

1000mg I.V. on D1 and at 6 month. After 6 month, in patients with response but not complete remission, Rituximab could be stopped or repeated with a 6 month-interval (12 month, 18 month, 24 month) until complete remission. Rituximab 1000mg I.V. will be repeated on the 15th day of each Rituximab infusion if CD19+ B cell count\>5/ul.

Trial Locations (1)

100730

RECRUITING

Peking Union Medical College Hospital, Beijing

All Listed Sponsors
lead

Peking Union Medical College Hospital

OTHER

NCT04745728 - Different Immunosuppressive Treatment in iMN | Biotech Hunter | Biotech Hunter