Repurposing Metformin As a Leukemia-preventive Drug in CCUS and LR-MDS

PHASE2RecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

December 13, 2021

Primary Completion Date

February 28, 2026

Study Completion Date

February 28, 2026

Conditions
PreleukemiaMyelodysplastic NeoplasmCytopeniaPreleukemic Anemia
Interventions
DRUG

Metformin

2000 mg/day metformin for 12 months (1000 mg b.i.d.) with a slow up-titration six weeks prior to full dose treatment.

Trial Locations (1)

2200

RECRUITING

Rigshospitalet, Copenhagen

All Listed Sponsors
collaborator

Steno Diabetes Center Copenhagen

OTHER

collaborator

Zealand University Hospital

OTHER

collaborator

Van Andel Research Institute

OTHER

collaborator

Herlev Hospital

OTHER

collaborator

Technical University of Denmark

OTHER

collaborator

Region Hovedstadens Apotek

OTHER_GOV

collaborator

University of Copenhagen

OTHER

lead

Kirsten Grønbæk

OTHER