A Phase III Study of Bevacizumab and Paclitaxel in Combination with Atezolizumab As a Treatment for Locally Advanced Unresectable or Metastatic Hormone Receptor-positive HER2 Negative Breast Cancer

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

280

Participants

Timeline

Start Date

January 21, 2021

Primary Completion Date

September 30, 2025

Study Completion Date

September 30, 2025

Conditions
Breast Cancer
Interventions
DRUG

Paclitaxel + bevacizumab therapy

"The following regimen will be continued as a 28-day course until disease progression or the criteria for treatment discontinuation are met.~\[Paclitaxel\] 90mg/m\^2, day1,8,15, IV \[Bevacizumab\] 10mg/kg, day1,15, IV"

DRUG

Paclitaxel + bevacizumab + atezolizumab

"The following regimen will be continued as a 28-day course until disease progression or the criteria for treatment discontinuation are met.~\[Atezolizumab\] 840 mg/body, day 1,15, IV \[Paclitaxel\] 90mg/m\^2, day1,8,15, IV \[Bevacizumab\] 10mg/kg, day1,15, IV"

Trial Locations (1)

Unknown

Cancer Institute Hospital of JFCR, Tokyo

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Chugai Pharmaceutical

INDUSTRY

lead

Japanese Foundation for Cancer Research

OTHER