A Study of CM24 in Combination with Nivolumab in Adults with Advanced Solid Tumors

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

79

Participants

Timeline

Start Date

March 19, 2021

Primary Completion Date

September 30, 2024

Study Completion Date

September 30, 2024

Conditions
Solid TumorNon Small Cell Lung CancerPancreatic CancerOvarian CancerPapillary Thyroid CancerMelanomaColorectal Adenocarcinoma
Interventions
DRUG

CM-24 and Nivolumab - Dose Escalation

Dose escalation of CM24 with nivolumab in adult patients with selected recurrent or metastatic solid tumors

DRUG

CM-24, Nivolumab, Nab paclitaxel and Gemcitabine - Expansion

Expansion cohort of CM24 in combination with nivolumab, nab-paclitaxel and gemcitabine in adult patients with advanced metastatic pancreatic cancer

DRUG

CM-24, Nivolumab, and Nal-IRI/5-FU/LV - Expansion

Expansion cohort of CM24 in combination with nivolumab and Nal-IRI/5-FU/LV in adult patients with advanced metastatic pancreatic cancer

DRUG

Nivolumab, Nab paclitaxel and Gemcitabine - Expansion

Expansion cohort of nivolumab in combination with nab-paclitaxel and gemcitabine in adult patients with advanced metastatic pancreatic cancer

DRUG

Nivolumab and Nal-IRI/5-FU/LV - Expansion

Expansion cohort of nivolumab in combination with Nal-IRI/5-FU/LV in adult patients with advanced metastatic pancreatic cancer

Trial Locations (18)

48201

Barbara Ann Karmanos Cancer Institute, Detroit

77030

The University of Texas M.D. Anderson Cancer Center, Houston

80045

University of Colorado, Aurora

85258

HonorHealth Research Institute, Scottsdale

06520

Yale University, New Haven

Unknown

Rambam Health Care Campus, Haifa

Sheba Medical Center, Ramat Gan

Hospital Clinic Barcelona, Barcelona

NEXT Oncology Barcelona, Barcelona

Vall d' Hebron Institute of Oncology (VHIO), Barcelona

Clinica Universidad de Navarra, Madrid

Hospital 12 Octubre, Madrid

Hospital General Universitario Gregorio Maranon, Madrid

Hospital South Texas Accelerated Research Therapeutics (START) Madrid - CIOCC, Madrid

South Texas Accelerated Research Therapeutics (START) Madrid - Hospital Fundacion Jimenez Diaz, Madrid

Clinica Universidad de Navarra - Pamplona, Pamplona

NEXT Oncology Madrid, Pozuelo de Alarcón

Hospital Quiron Salud Valencia, Valencia

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Bristol-Myers Squibb

INDUSTRY

lead

Famewave Ltd.

INDUSTRY