Treating Early-stage Non-Small Cell Lung Cancer With Durvalumab and Radiation Therapy

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

13

Participants

Timeline

Start Date

January 27, 2021

Primary Completion Date

February 28, 2026

Study Completion Date

February 28, 2026

Conditions
NSCLCNon-small Cell Lung CancerLung CancerNon-small Cell Lung Cancer Stage INon-small Cell Lung Cancer Stage IINon-small Cell Lung Cancer Stage IIINon-small Cell Lung Cancer Stage IIIAPD-L1 Gene Mutation
Interventions
DRUG

Durvalumab

Patients will receive durvalumab 1500mg durvalumab via IV infusion over 1 hour, once every 4 weeks (Q4W) for up to a maximum of 6 months (up to 6 doses/cycles) unless there is unacceptable toxicity, withdrawal of consent, or another discontinuation criterion is met.

RADIATION

Stereotactic Body Radiation Therapy

Radiation therapy will be performed with external beam ionizing radiation in accordance with institutional standard practice. 3D conformal radiation therapy (3D-CRT), intensity-modulated radiation therapy (IMRT) or volumetric arc therapy (VMAT) will be used at the discretion of the treating radiation oncologist.

Trial Locations (9)

10065

Memorial Sloan Kettering Cancer Center, New York

10604

Memorial Sloan Kettering Westchester, Harrison

11553

Memorial Sloan Kettering Nassau, Rockville Centre

11725

Memorial Sloan Kettering Cancer Center @ Suffolk - Commack, Commack

33143

Baptist Alliance - McI, Miami

06102

Hartford Healthcare (Data Collection), Hartford

07920

Memorial Sloan Kettering Basking Ridge, Basking Ridge

07748

Memorial Sloan Kettering Monmouth, Middletown

07645

Memorial Sloan Kettering Bergen, Montvale

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

lead

Memorial Sloan Kettering Cancer Center

OTHER

NCT04716946 - Treating Early-stage Non-Small Cell Lung Cancer With Durvalumab and Radiation Therapy | Biotech Hunter | Biotech Hunter