NCT04704661 - Testing the Combination of Two Anti-cancer Drugs, DS-8201a and AZD6738, for The Treatment of Advanced Solid Tumors Expressing the HER2 Protein or Gene, The DASH Trial | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

August 9, 2021

Primary Completion Date

March 31, 2026

Study Completion Date

March 31, 2026

Conditions

Advanced Breast CarcinomaAdvanced Colon CarcinomaAdvanced Colorectal CarcinomaAdvanced Endometrial CarcinomaAdvanced Gastric CarcinomaAdvanced Gastroesophageal Junction AdenocarcinomaAdvanced Malignant Solid NeoplasmAdvanced Salivary Gland CarcinomaAnatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Clinical Stage III Gastric Cancer AJCC v8Clinical Stage III Gastroesophageal Junction Adenocarcinoma AJCC v8Clinical Stage IV Gastric Cancer AJCC v8Clinical Stage IV Gastroesophageal Junction Adenocarcinoma AJCC v8HER2-Positive Breast CarcinomaMalignant Hepatobiliary NeoplasmMetastatic Breast CarcinomaMetastatic Colon CarcinomaMetastatic Colorectal CarcinomaMetastatic Endometrial CarcinomaMetastatic Gastric CarcinomaMetastatic Gastroesophageal Junction AdenocarcinomaMetastatic Malignant Solid NeoplasmMetastatic Salivary Gland CarcinomaStage III Colon Cancer AJCC v8Stage III Colorectal Cancer AJCC v8Stage III Major Salivary Gland Cancer AJCC v8Stage III Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8Stage IV Colon Cancer AJCC v8Stage IV Colorectal Cancer AJCC v8Stage IV Major Salivary Gland Cancer AJCC v8Stage IV Uterine Corpus Carcinoma or Carcinosarcoma AJCC v8Unresectable Breast CarcinomaUnresectable Colon CarcinomaUnresectable Colorectal CarcinomaUnresectable Endometrial CarcinomaUnresectable Gastric CarcinomaUnresectable Gastroesophageal Junction AdenocarcinomaUnresectable Malignant Solid NeoplasmUnresectable Salivary Gland Carcinoma

Interventions

PROCEDURE

Biopsy Procedure

Undergo tissue biopsy

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

DRUG

Ceralasertib

Given PO

PROCEDURE

Computed Tomography

Undergo CT or PET/CT

PROCEDURE

Echocardiography Test

Undergo ECHO

PROCEDURE

Multigated Acquisition Scan

Undergo MUGA

PROCEDURE

Positron Emission Tomography

Undergo PET/CT

BIOLOGICAL

Trastuzumab Deruxtecan

Given IV

Trial Locations (23)

10065

RECRUITING

NYP/Weill Cornell Medical Center, New York

19107

RECRUITING

Thomas Jefferson University Hospital, Philadelphia

20892

ACTIVE_NOT_RECRUITING

National Cancer Institute Developmental Therapeutics Clinic, Bethesda

ACTIVE_NOT_RECRUITING

National Institutes of Health Clinical Center, Bethesda

32610

RECRUITING

University of Florida Health Science Center - Gainesville, Gainesville

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

62269

RECRUITING

Memorial Hospital East, Shiloh

63110

RECRUITING

Washington University School of Medicine, St Louis

63129

RECRUITING

Siteman Cancer Center-South County, St Louis

63136

RECRUITING

Siteman Cancer Center at Christian Hospital, St Louis

63141

RECRUITING

Siteman Cancer Center at West County Hospital, Creve Coeur

63376

RECRUITING

Siteman Cancer Center at Saint Peters Hospital, City of Saint Peters

73104

RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

75390

RECRUITING

UT Southwestern/Simmons Cancer Center-Dallas, Dallas

77030

RECRUITING

M D Anderson Cancer Center, Houston

78712

RECRUITING

University of Texas at Austin, Austin

84112

RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

90033

RECRUITING

Los Angeles General Medical Center, Los Angeles

RECRUITING

USC / Norris Comprehensive Cancer Center, Los Angeles

92612

RECRUITING

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care, Irvine

92868

RECRUITING

UC Irvine Health/Chao Family Comprehensive Cancer Center, Orange

95817

RECRUITING

University of California Davis Comprehensive Cancer Center, Sacramento

77555-0565

RECRUITING

University of Texas Medical Branch, Galveston

All Listed Sponsors

lead

National Cancer Institute (NCI)

NIH