Efficacy and Safety of First-line Anti-PD-1/PD-L1 Monoclonal Antibody in Combination With Chemotherapy and Bronchoscopy-assisted Interventional Therapy in Patients With Advanced Central Non-small Cell Lung Cancer

PHASE2/PHASE3Not yet recruitingINTERVENTIONAL
Enrollment

80

Participants

Timeline

Start Date

January 20, 2021

Primary Completion Date

March 31, 2022

Study Completion Date

January 20, 2026

Conditions
Advanced Lung CarcinomaNon-small Cell Lung Cancer
Interventions
DRUG

Anti-PD-1/PD-L1 Monoclonal Antibody,Chemotherapy

Anti-PD-1/PD-L1 monoclonal antibody (approved anti-PD-1/PD-L1 monoclonal antibody);albumin paclitaxel/docetaxel + carboplatin (albumin paclitaxel 130mg/m2, d1 d8, Docetaxel 75mg/m2, carboplatin AUC=5, d1, every 21 days, 4 cycles of chemotherapy; immunotherapy no more than 2 years)

DEVICE

Bronchoscopy-assisted Interventional Therapy

Bronchoscopy-assisted interventional therapy (1 time before chemotherapy or 2 times before chemotherapy and before the third cycle of treatment)

All Listed Sponsors
lead

Shanghai Pulmonary Hospital, Shanghai, China

OTHER