Microdevice In Ovarian, Fallopian Tube, And Peritoneal Cancer

PHASE1RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

November 1, 2022

Primary Completion Date

June 5, 2026

Study Completion Date

June 30, 2026

Conditions
Ovarian CancerFallopian Tube CancerPeritoneal CancerOvarian Cancer Stage IIIOvarian Cancer Stage IVFallopian Tube Cancer Stage IVFallopian Tube Cancer Stage III
Interventions
COMBINATION_PRODUCT

Microdevice

"Placement of 1 to 6 implantable microdevices with multiple miniature drug reservoirs into a tumor mass 24 +/- 8 hours prior to surgery. Drugs will be released over 24 (+/- 8) hours while the microdevice is in the tumor prior to retrieval. The local tissue is retrieved along with the microdevice and no residual drug will remain.~* Each microdevice will harbor up to 20 drugs and drug combinations relevant to the treatment of ovarian cancer.~* Each drug or drug combination will be released from a single, separate reservoir. At least two reservoirs will harbor a drug vehicle only.~* Drugs will include all or a subset of the following: Cisplatin, Carboplatin, Paclitaxel, Doxorubicin or pegylated liposomal doxorubicin (PLD), Cyclophosphamide, Etoposide, Gemcitabine, Ifosfamide, Pemetrexed, Topotecan, Vinorelbine, Olaparib, Niraparib, Rucaparib, Carboplatin + paclitaxel (combination), Carboplatin + doxorubicin (combination),Carboplatin + gemcitabine (combination)"

Trial Locations (2)

02115

RECRUITING

Brigham and Women's Hospital, Boston

02215

RECRUITING

Dana Farber Cancer Institute, Boston

All Listed Sponsors
collaborator

National Cancer Institute (NCI)

NIH

collaborator

Dana-Farber Cancer Institute

OTHER

lead

Brigham and Women's Hospital

OTHER