A Histamine Pharmacodynamic Biomarker to Guide Treatment in Pediatric Asthma (HAS3)

PHASE3RecruitingINTERVENTIONAL
Enrollment

300

Participants

Timeline

Start Date

April 28, 2021

Primary Completion Date

May 1, 2026

Study Completion Date

May 1, 2026

Conditions
Allergic Asthma
Interventions
DRUG

Levocetirizine Dihydrochloride

At the end of the HILD assessment participants will be randomized to Levocetirizine Dihydrochloride or placebo. Children will be randomized by an investigational pharmacist to add-on either Levocetirizine dihydrochloride/ Xyzal® (UCB, Inc.) immediate release oral solution 2.5mg/5ml (2.5mg in children 6-11 years of age; 5mg in children \>11 years per recommended doses) or placebo to their current asthma regimen.

DRUG

Placebo

Placebo

Trial Locations (1)

64108

RECRUITING

Children's Mercy Hospital, Kansas City

All Listed Sponsors
collaborator

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

NIH

lead

Bridgette Jones

OTHER