Study of JDQ443 in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

344

Participants

Timeline

Start Date

February 24, 2021

Primary Completion Date

August 26, 2026

Study Completion Date

August 26, 2026

Conditions
KRAS G12C Mutant Solid TumorsCarcinoma, Non-Small-Cell LungCarcinoma, ColorectalCancer of LungCancer of the LungLung CancerNeoplasms, LungNeoplasms, PulmonaryPulmonary CancerPulmonary Neoplasms
Interventions
DRUG

JDQ443

KRAS G12C inhibitor

DRUG

TNO155

SHP2 inhibitor

BIOLOGICAL

tislelizumab

Anti PD1 antibody

Trial Locations (37)

3000

Novartis Investigative Site, Melbourne

Novartis Investigative Site, Leuven

10002

Novartis Investigative Site, Taipei

13273

Novartis Investigative Site, Marseille

15232

Hillman Cancer Center, Pittsburgh

15706

Novartis Investigative Site, Santiago de Compostela

20133

Novartis Investigative Site, Milan

20162

Novartis Investigative Site, Milan

25123

Novartis Investigative Site, Brescia

28050

Novartis Investigative Site, Madrid

29010

Novartis Investigative Site, Málaga

30322

Emory University School of Medicine-Winship Cancer Institute, Atlanta

45147

Novartis Investigative Site, Essen

46010

Novartis Investigative Site, Valencia

50937

Novartis Investigative Site, Cologne

69373

Novartis Investigative Site, Lyon

77030

Uni Of TX MD Anderson Cancer Cntr, Houston

79106

Novartis Investigative Site, Freiburg im Breisgau

94800

Novartis Investigative Site, Villejuif

100036

Novartis Investigative Site, Beijing

119074

Novartis Investigative Site, Singapore

168583

Novartis Investigative Site, Singapore

510080

Novartis Investigative Site, Guangzhou

999077

Novartis Investigative Site, Hong Kong

02114

Massachusetts General Hospital Cancer Center, Boston

H2W 1T8

Novartis Investigative Site, Montreal

DK-2100

Novartis Investigative Site, Copenhagen

01307

Novartis Investigative Site, Dresden

466 8560

Novartis Investigative Site, Nagoya

277 8577

Novartis Investigative Site, Kashiwa

541-8567

Novartis Investigative Site, Osaka

104 0045

Novartis Investigative Site, Chuo Ku

135 8550

Novartis Investigative Site, Koto Ku

1066 CX

Novartis Investigative Site, Amsterdam

03722

Novartis Investigative Site, Seoul

08035

Novartis Investigative Site, Barcelona

08907

Novartis Investigative Site, L'Hospitalet de Llobregat

Sponsors
All Listed Sponsors
lead

Novartis Pharmaceuticals

INDUSTRY