DFMO as Maintenance Therapy for Molecular High/Very High Risk and Relapsed Medulloblastoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

118

Participants

Timeline

Start Date

March 29, 2021

Primary Completion Date

March 31, 2028

Study Completion Date

March 31, 2029

Conditions
Medulloblastoma
Interventions
DRUG

Difluoromethylornithine

"DFMO (difluoromethylornithine is an inhibitor of ornithine decarboxylase (ODC) designated chemically as 2-(difluoromethyl)-DL-ornithine monohydrochloride monohydrate.~The dosage form to be used in this study is provided as a convex tablet containing 192 mg eflornithine (equivalent to 250 mg of eflornithine HCl, monohydrate). The tablets are packaged and sealed in opaque white HDPE bottles, and each bottle contains 100 tablets. The DMFO tablets are supplied by USWorldMeds (USWM).~The tablets are to be stored at room temperature (20-250C)."

Trial Locations (15)

17033

RECRUITING

Penn State Milton S. Hershey Medical Center and Children's Hospital, Hershey

28204

RECRUITING

Levine Children's Hospital, Charlotte

29425

RECRUITING

Medical University of South Carolina, Charleston

32806

RECRUITING

Arnold Palmer Hospital for Children, Orlando

33607

RECRUITING

St. Joseph's Children's Hospital, Tampa

40202

RECRUITING

University of Louisville/Norton's Children's, Louisville

40502

RECRUITING

Kentucky Children's Hospital, Lexington

63104

NOT_YET_RECRUITING

Cardinal Glennon Children's Medical Center, St Louis

64108

RECRUITING

Children's Mercy Hospitals and Clinics, Kansas City

72202

RECRUITING

Arkansas Children's Hospital, Little Rock

78723

RECRUITING

Dell Children's Blood and Cancer Center, Austin

92123

RECRUITING

Rady Children's Hospital, San Diego

94609

RECRUITING

UCSF Benioff Children's Hospital Oakland-, Oakland

06106

NOT_YET_RECRUITING

Connecticut Children's Hospital, Hartford

07601

RECRUITING

Hackensack University Medical Center, Hackensack

All Listed Sponsors
lead

Giselle Sholler

OTHER