Senolytic Therapy to Modulate the Progression of Alzheimer's Disease (SToMP-AD) Study

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

48

Participants

Timeline

Start Date

December 22, 2021

Primary Completion Date

January 31, 2028

Study Completion Date

January 31, 2029

Conditions
Alzheimer Disease, Early OnsetMild Cognitive Impairment
Interventions
DRUG

Dasatinib + Quercetin

D+Q will be administered once daily (1st dose of each cycle will be given, supervised, at the clinic visit; the 2nd dose will be taken at home) for 2 consecutive days followed by a 13-day (+/- 2 day) no-drug period for 12 consecutive weeks for 6 rounds of administration.

OTHER

Placebo Capsules

Matching placebo capsules following the same administration protocol as the experimental treatment - administered once daily (1st dose of each cycle will be given, supervised, at the clinic visit; the 2nd dose will be taken at home) for 2 consecutive days followed by a 13-day (+/- 2 day) no-drug period for 12 consecutive weeks for 6 rounds of administration.

Trial Locations (5)

27157

Wake Forest Health Sciences, Winston-Salem

Unknown

Fundación ACE Clinical Site, Barcelona

Hospital Clínic de Barcelona Site, Barcelona

Sant Pau Clinical Site, Barcelona

FISEVI Clinical Site, Seville

All Listed Sponsors
collaborator

The University of Texas Health Science Center at San Antonio

OTHER

collaborator

Wake Forest University Health Sciences

OTHER

lead

Washington University School of Medicine

OTHER