SG301 Safety Study in Subjects With Relapsed or Refractory Multiple Myeloma and Other Hematological Malignancies

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

61

Participants

Timeline

Start Date

November 4, 2021

Primary Completion Date

June 30, 2024

Study Completion Date

June 30, 2026

Conditions
Relapsed or Refractory Multiple MyelomaHematological Malignancy
Interventions
DRUG

SG301

Phase 1a will use an accelerated titration and 3+3 design with 9 dose cohorts: 0.005 mg/kg, 0.05 mg/kg,0.5 mg/kg, 1 mg/kg, 2 mg/kg, 4 mg/kg, 8 mg/kg, 12 mg/kg and 16 mg/kg by IV infusion. Accelerated titration (i.e., 1 patient each) will be applied to the first 3 cohorts.

Trial Locations (14)

100020

Affiliated Beijing Chaoyang Hospital of Capital Medical University, Beijing

100032

Beijing Jishuitan Hostipal, Beijing

110002

The First Affiliated Hospital of China Medical University, Shenyang

110136

Shengjing Hospital Affiliated to China Medical University, Shenyang

214125

Wuxi Central Hospital, Wuxi

233099

The First Affiliated Hospital of Bengbu Medical College, Bengbu

250063

Qilu Hospital of Shandong University, Jinan

310003

The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou

430062

Wuhan University Central South Hospital, Wuhan

441021

Xiangyang Central Hospital, Xiangyang

450003

Henan Cancer Hospital, Zhengzhou

518025

Shenzhen Second People's Hospital, Shenzhen

050011

The Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang

030032

Shanxi Norman Bethune Hospital, Taiyuan

All Listed Sponsors
lead

Hangzhou Sumgen Biotech Co., Ltd.

INDUSTRY