Study of RET Inhibitor TAS0953/HM06 in Patients with Advanced Solid Tumors with RET Gene Abnormalities

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

244

Participants

Timeline

Start Date

December 16, 2020

Primary Completion Date

March 31, 2030

Study Completion Date

March 31, 2031

Conditions
RET-altered Non Small Cell Lung CancerRET-altered Solid Tumors
Interventions
DRUG

TAS0953/HM06

Phase 1: oral, starting dose 20mg twice a day, until recommended phase 2 dose, continuous daily dosing, cycles lasting 21 days

DRUG

TAS0953/HM06

Phase 2: oral, recommended dose twice a day, continuous daily dosing, cycles lasting 21 days

Trial Locations (17)

10016

TERMINATED

Laura and Isaac Perlmutter Cancer Center at NYU Langone Health, New York

10065

TERMINATED

Memorial Sloan Kettering Cancer Center, New York

37203

TERMINATED

The Sarah Cannon Research Institute/Tennessee Oncology, Nashville

48202

TERMINATED

Henry Ford Hospital, Detroit

49546

TERMINATED

START Midwest - Cancer & Hematology Centers of Western Michigan, Grand Rapids

92868-3298

TERMINATED

Chao Family Comprehensive Cancer Center, Orange

94305-5826

TERMINATED

Stanford Cancer Center, Stanford

02114

TERMINATED

Massachusetts General Hospital, Boston

77030-4009

TERMINATED

The University of Texas M. D. Anderson Cancer Center, Houston

Unknown

RECRUITING

National Cancer Center Hospital East, Kashiwa-shi

RECRUITING

Tohoku University Hospital, Sendai

RECRUITING

Okayama University Hospital, Okayama

RECRUITING

Kansai Medical University Hospital, Hirakata-shi

RECRUITING

Osaka International Cancer Institute, Osaka

RECRUITING

Shizuoka Cancer Center, Shunto-gun

104-0045

RECRUITING

National Cancer Center Hospital, Chuo-ku

135-8550

RECRUITING

The Cancer Institute Hospital of JFCR, Koto-ku

All Listed Sponsors
lead

Taiho Pharmaceutical Co., Ltd.

INDUSTRY