Comparison of Two sTRAtegies For the Non-Invasive Diagnosis of advanCed Liver Fibrosis in NAFLD

NARecruitingINTERVENTIONAL
Enrollment

1,045

Participants

Timeline

Start Date

April 7, 2022

Primary Completion Date

October 7, 2028

Study Completion Date

December 7, 2028

Conditions
NAFLD
Interventions
DIAGNOSTIC_TEST

blood tests

"Single arm : all NAFLD patients evaluating the FIB4-FS and the eLIFT-FMVCTE with two patient groups considered at inclusion:~Low-risk group (neither metabolic syndrome nor AST ≥35 UI/l): Liver biopsy won't be mandatory in this group because of the very low risk of advanced fibrosis (4%). These patients will be considered as having no-mild F0-2 liver fibrosis and the study visit will be scheduled for clinical data recording, blood sampling, and LSM with Fibroscan. Liver biopsy could still be performed in the low-risk group if the investigator deems it is required for the clinical management of the patient.~At-risk group (presence of a metabolic syndrome and/or AST ≥35 UI/l): Because of the increased prevalence of significant liver lesions in this group, the patients will have a liver biopsy with clinical data recording, blood sampling, and Fibroscan the same day."

Trial Locations (15)

Unknown

RECRUITING

University Hospital of Angers, Angers

NOT_YET_RECRUITING

Avicenne Hospital (Greater Paris University Hospitals), Bobigny

RECRUITING

University Hospital of Dijon, Dijon

RECRUITING

Departemental Hospital Center of Vendée, La Roche-sur-Yon

ACTIVE_NOT_RECRUITING

University Hospital of Grenoble, La Tronche

ACTIVE_NOT_RECRUITING

University Hospital of Lille, Lille

ACTIVE_NOT_RECRUITING

University Hospital of Limoges, Limoges

RECRUITING

La Croix Rousse Hospital, Lyon

RECRUITING

University Hospital of Montpellier, Montpellier

ACTIVE_NOT_RECRUITING

University Hospital of Nantes, Nantes

NOT_YET_RECRUITING

La Pitié Salpétrière Hospital (Greater Paris University Hospitals), Paris

ACTIVE_NOT_RECRUITING

Saint-Antoine Hospital (Greater Paris University Hospitals), Paris

ACTIVE_NOT_RECRUITING

University Hospital of Bordeaux, Pessac

ACTIVE_NOT_RECRUITING

University Hospital of Rennes, Rennes

ACTIVE_NOT_RECRUITING

University Hospital of Tours, Tours

All Listed Sponsors
lead

University Hospital, Angers

OTHER_GOV