GDNF Gene Therapy for Multiple System Atrophy

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

9

Participants

Timeline

Start Date

October 3, 2023

Primary Completion Date

August 31, 2026

Study Completion Date

August 31, 2028

Conditions
Multiple System Atrophy
Interventions
BIOLOGICAL

AAV2-GDNF gene therapy

Bilateral image-guided infusion of AAV2-GDNF into putamen, single dose

PROCEDURE

Sham (Placebo) Surgery

Bilateral partial burr/twist holes without dural penetration

Trial Locations (7)

10016

NYU Langone Health, New York

33486

Parkinson's Disease and Movement Disorders Center of Boca Raton, Boca Raton

37232

Vanderbilt University Medical Center, Nashville

43210

The Ohio State University Medical Center, Columbus

48334

Quest Research Institute, Farmington Hills

92697

University of California Irvine, Irvine

02114

Massachusetts General Hospital, Boston

Sponsors
All Listed Sponsors
lead

Brain Neurotherapy Bio, Inc.

INDUSTRY

NCT04680065 - GDNF Gene Therapy for Multiple System Atrophy | Biotech Hunter | Biotech Hunter