Polatuzumab Vedotin in Combination With Chemotherapy in Subjects With Richter's Transformation

PHASE2RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

September 24, 2021

Primary Completion Date

September 30, 2026

Study Completion Date

September 30, 2027

Conditions
Richter SyndromeChronic Lymphocytic Leukemia
Interventions
DRUG

Polatuzumab Vedotin

Polatuzumab vedotin will be administered as an IV infusion at 1.8mg/kg on Day 1 of each cycle, every 21 days.

DRUG

Rituximab

Rituximab will be obtained from commercial supply, and will be given for a total of 6 cycles for all patients. The drug will be given by IV route.

DRUG

Etoposide

Etoposide will be obtained from commercial supply, and will be given for a total of 6 cycles for all patients. The drug will be given by IV route.

DRUG

Prednisone

Prednisone will be obtained from commercial supply, and will be given for a total of 6 cycles for all patients. Prednisone will be given orally.

DRUG

Cyclophosphamide

Cyclophosphamide will be obtained from commercial supply, and will be given for a total of 6 cycles for all patients. The drug will be given by IV route.

DRUG

Hydroxydaunomycin

Hydroxydaunomycin will be obtained from commercial supply, and will be given for a total of 6 cycles for all patients. The drug will be given by IV route.

Trial Locations (4)

10029

RECRUITING

Mount Sinai- Icahn School of Medicine, New York

10032

RECRUITING

Columbia University Medical Center, New York

10065

RECRUITING

Weill Cornell Medicine, New York

43210

RECRUITING

Ohio state University, Columbus

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Genentech, Inc.

INDUSTRY

lead

Weill Medical College of Cornell University

OTHER