Nimotuzumab Combined With Chemoradiotherapy Versus Chemoradiotherapy for Local Advanced Cervical Squamous Cell Carcinoma

NANot yet recruitingINTERVENTIONAL
Enrollment

286

Participants

Timeline

Start Date

December 31, 2020

Primary Completion Date

December 31, 2024

Study Completion Date

December 31, 2025

Conditions
Cervical Squamous Cell Carcinoma
Interventions
DRUG

Nimotuzumab

Patients receive Nimotuzumab 400 mg each time, once a week, slow intravenous drip, for a total of 6 weeks.

DRUG

Cisplatin

Patients receive 40 mg/m2, d1, 7 days as 1 treatment cycle, 6 treatment cycles in total

RADIATION

External-beam radiation

Patients undergo IMRT/VMAT radiotherapy with pelvic and/or extended field irradiation at a total dose of 45 - 50.4 Gy; 1.8 - 2.0 Gy/f, 25 - 28 f.

RADIATION

Brachytherapy

Patient undergo Brachytherapy with high dose rate, with a total dose of 30-40 Gy and a cumulative dose of 80 \~ 85 Gy at point A/HRCTV D90; if the tumor diameter is ≥ 4 cm, the cumulative dose of ≥ 87 Gy at point A/HRCTV D90.

Trial Locations (1)

100191

Peking University 3rd Hospital, Beijing

All Listed Sponsors
lead

Peking University Third Hospital

OTHER

NCT04678791 - Nimotuzumab Combined With Chemoradiotherapy Versus Chemoradiotherapy for Local Advanced Cervical Squamous Cell Carcinoma | Biotech Hunter | Biotech Hunter