A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies

PHASE1RecruitingINTERVENTIONAL
Enrollment

134

Participants

Timeline

Start Date

March 3, 2021

Primary Completion Date

December 15, 2026

Study Completion Date

January 30, 2027

Conditions
Advanced Malignant Solid NeoplasmRAS MutationLung CancerColon CancerGlioblastomaPancreatic Cancer
Interventions
DRUG

RSC-1255 Dose Escalation

Phase 1a will enroll 30-40 participants to identify the dose limiting toxicity (DLT), recommended Phase 1b dose, and the safety and tolerability of RSC-1255. RSC-1255 is administered orally twice daily, without food. Each cycle is 21 days.

DRUG

RSC-1255 Dose Expansion

Phase 1b will enroll 48-104 participants to further characterize the safety, pharmacology, and clinical efficacy of RSC-1255. RSC-1255 is administered orally twice daily, without food. Each cycle is 21 days.

Trial Locations (3)

37203

RECRUITING

Sarah Cannon, SCRI Oncology Partners, Nashville

80218

RECRUITING

Sarah Cannon, SCRI Oncology Partners - Health One, Denver

90404

RECRUITING

University of California, Los Angles (UCLA) Department of Medicine - Hematology/Oncology, Los Angeles

All Listed Sponsors
lead

RasCal Therapeutics, Inc.

INDUSTRY