1,200
Participants
Start Date
May 7, 2021
Primary Completion Date
September 30, 2026
Study Completion Date
March 31, 2027
Standard of care
Participants in the control group will receive standard of care treatment for their injury, to include all institution specific standard treatment (prophylactic and otherwise) for preventing and treating infection.
Vancomycin and Tobramycin
The patients in the SEXTANT cohort will have 1000 mg of Vancomycin and 1200 mg of Tobramycin administered to the wound surface, fracture site and exposed hardware (if any) just prior to suture closure of the wound or flap. The SEXTANT cohort will then receive at least 72 hours of systemic antibiotic therapy targeted to the modern wound bioburden.
RECRUITING
Jamaica Hospital Medical Center, Jamaica
RECRUITING
Temple University, Philadelphia
RECRUITING
Walter Reed Military Medical Center, Bethesda
RECRUITING
University of Maryland , MD Department of Orthopaedics, Baltimore
RECRUITING
Inova Fairfax MEdical Campus, Falls Church
RECRUITING
University of Virginia, Charlottesville
RECRUITING
Virginia Commonwealth University Medical Center, Richmond
RECRUITING
Atrium Health Wake Forest Baptist, Winston-Salem
RECRUITING
University of North Carolina at Chapel Hill, Chapel Hill
RECRUITING
Atrium Health Carolinas Medical Center, Charlotte
RECRUITING
Emory University School of Medicine, Atlanta
RECRUITING
St Mary's University/Tenent Health, West Palm Beach
RECRUITING
Vanderbilt University Medical Center, Nashville
RECRUITING
University of Mississippi Medical Center, Jackson
RECRUITING
University of Kentucky, Lexington
RECRUITING
Ohio State University Wexner Medical Center, Columbus
RECRUITING
METROHealth, Cleveland
RECRUITING
Indiana University School of Medicine - Methodist Hospital, Indianapolis
RECRUITING
Indiana University/Eskenazi Health, Indianapolis
RECRUITING
Hennepin County Medical Center / Minneapolis, Minneapolis
RECRUITING
LSU Health Sciences, New Orleans
RECRUITING
University of Oklahoma College of Medicine, Oklahoma City
RECRUITING
University of Texas Health Science Center - Houston, Houston
RECRUITING
University of Colorado Anschutz Medical Campus, Aurora
RECRUITING
Stanford University, Redwood City
RECRUITING
_University of California, San Francisco, San Francisco
RECRUITING
University of California at San Francisco, San Francisco
RECRUITING
Harvard/Mass General/Brigham Hospitals, Boston
RECRUITING
Dartmouth Hitchcock, Lebanon
RECRUITING
Brown University/Rhode Island Hospital, Providence
RECRUITING
Rhode Island Hospital/Brown University, Providence
United States Department of Defense
FED
Major Extremity Trauma Research Consortium
OTHER