NCT04665739View on ClinicalTrials.gov

Testing Lutetium Lu 177 Dotatate in Patients With Somatostatin Receptor Positive Advanced Bronchial Neuroendocrine Tumors

PHASE2RecruitingINTERVENTIONAL
Enrollment

70

Participants

Timeline

Start Date

February 3, 2023

Primary Completion Date

July 1, 2026

Study Completion Date

January 16, 2033

Conditions
Advanced Lung Neuroendocrine TumorFunctioning Lung Neuroendocrine TumorLocally Advanced Lung Neuroendocrine NeoplasmLung Neuroendocrine NeoplasmLung Neuroendocrine Tumor G1Lung Neuroendocrine Tumor G2Metastatic Lung Neuroendocrine NeoplasmMetastatic Lung Neuroendocrine TumorNon-Functioning Lung Neuroendocrine TumorRecurrent Lung Neuroendocrine NeoplasmUnresectable Lung Neuroendocrine NeoplasmUnresectable Lung Neuroendocrine Tumor
Interventions
PROCEDURE

Biospecimen Collection

Undergo blood and tissue sample collection

PROCEDURE

Computed Tomography

Undergo CT

DRUG

Everolimus

Given PO

OTHER

Fludeoxyglucose F-18

Given FDG

DRUG

Lutetium Lu 177 Dotatate

Given IV

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Positron Emission Tomography

Undergo PET

PROCEDURE

Single Photon Emission Computed Tomography

Undergo SPECT

OTHER

Survey Administration

Ancillary studies

Trial Locations (29)

15232

RECRUITING

University of Pittsburgh Cancer Institute (UPCI), Pittsburgh

19111

RECRUITING

Fox Chase Cancer Center, Philadelphia

19140

RECRUITING

Temple University Hospital, Philadelphia

20007

RECRUITING

MedStar Georgetown University Hospital, Washington D.C.

27710

RECRUITING

Duke University Medical Center, Durham

33136

RECRUITING

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami

33146

RECRUITING

UM Sylvester Comprehensive Cancer Center at Coral Gables, Coral Gables

33180

RECRUITING

UM Sylvester Comprehensive Cancer Center at Aventura, Aventura

33324

RECRUITING

UM Sylvester Comprehensive Cancer Center at Plantation, Plantation

33442

RECRUITING

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach

35233

ACTIVE_NOT_RECRUITING

University of Alabama at Birmingham Cancer Center, Birmingham

37232

SUSPENDED

Vanderbilt University/Ingram Cancer Center, Nashville

43210

RECRUITING

Ohio State University Comprehensive Cancer Center, Columbus

44106

RECRUITING

Case Western Reserve University, Cleveland

50023

RECRUITING

UI Health Care Mission Cancer and Blood - Ankeny Clinic, Ankeny

50309

RECRUITING

Iowa Methodist Medical Center, Des Moines

RECRUITING

UI Health Care Mission Cancer and Blood - Des Moines Clinic, Des Moines

55905

RECRUITING

Mayo Clinic in Rochester, Rochester

60451

RECRUITING

UC Comprehensive Cancer Center at Silver Cross, New Lenox

60462

RECRUITING

University of Chicago Medicine-Orland Park, Orland Park

60637

RECRUITING

University of Chicago Comprehensive Cancer Center, Chicago

63131

RECRUITING

Missouri Baptist Medical Center, St Louis

84112

RECRUITING

Huntsman Cancer Institute/University of Utah, Salt Lake City

90048

RECRUITING

Cedars Sinai Medical Center, Los Angeles

90211

RECRUITING

Tower Cancer Research Foundation, Beverly Hills

90505

RECRUITING

Torrance Memorial Physician Network - Cancer Care, Torrance

92354

RECRUITING

Loma Linda University Medical Center, Loma Linda

94158

RECRUITING

UCSF Medical Center-Mission Bay, San Francisco

02215

RECRUITING

Dana-Farber Cancer Institute, Boston

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH