An Open Label Study Evaluating the Efficacy and Safety of Etrumadenant (AB928) Based Treatment Combinations in Participants With Metastatic Colorectal Cancer.

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

227

Participants

Timeline

Start Date

May 10, 2021

Primary Completion Date

September 5, 2025

Study Completion Date

September 5, 2025

Conditions
Metastatic Colorectal Cancer
Interventions
DRUG

AB680

AB680 is a cluster of differentiated CD73 Inhibitor

DRUG

Etrumadenant

Etrumadenant is a dual adenosine receptor (A2aR and A2bR) antagonist

DRUG

Zimberelimab

Zimberelimab is a fully human anti-PD-1 monoclonal antibody

DRUG

Bevacizumab

Bevacizumab is administered as part of standard chemotherapy regimen

DRUG

m-FOLFOX-6 regimen

mFOLFOX-6 regimen is administered as part of standard chemotherapy regimen

DRUG

Regorafenib

Regorafenib is administered as part of standard chemotherapy regimen

Trial Locations (44)

3080

Seoul National University Hospital (SNUH), Seoul

6351

Samsung Medical Center, Seoul

8208

Corporacio Sanitaria Parc Tauli, Sabadell

8241

Korea University Anam Hospital, Seoul

10016

NYU Langone Medical Center - NYU Medical Oncology Associates, New York

10032

New York-Presbyterian Hospital-Columbia University Medical Center, New York

13620

Seoul National University Bundang Hospital, Seoul

20089

Istituto Clinico Humanitas IRCCS, Rozzano

20141

Azienda Ospedaliera Niguarda Ca' Granda, Milan

20162

Instituto Europeo di Oncologia, Milan

20817

American Oncology Partners of Maryland PA, Bethesda

21000

Centre Georges Francois Leclerc, Dijon

28007

Hospital Universitario La Paz, Madrid

28046

Hospital General Universitario Gregorio Maranon, Madrid

29605

Prisma Health-Upstate, Greenville

30322

Winship Cancer Institute at Emory University, Atlanta

31008

Clinica Universidad Navarra-Sede Madrid, Pamplona

32005

Complejo Hospitalario de Orense, Ourense

33076

Institut Bergonie - Centre Regional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest, Bordeaux

37203

Vanderbilt-Ingram Cancer Center, Nashville

37232

Sarah Cannon Research Institute, Nashville

44093

Hopital Hotel Dieu, Nantes

50134

Azienda Ospedaliero Universitaria Careggi-S.O.D. Patologia Medica, Florence

53100

Universita di Siena - Azienda Ospedaliera Universitaria Senese-Policlincio Santa Maria Alle Scotte, Siena

53792

University of Wisconsin School of Medicine, Madison

58128

Chonnam National University Hwasun Hospital, Hwasun

63110

Washington University School of Medicine, St Louis

70013

IRCCS - Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis, Castellana Grotte

70121

Ochsner Medical Center (OMC), New Orleans

75012

Hopital Saint Antoine, Paris

75651

Groupe Hospitalier Pitie-Salpetriere-Centre De Recherche et de Medecine de l'Obesite, Paris

77030

The University of Texas MD Anderson Cancer Center, Houston

85715

Arizona Clinical Research Center Inc, Tucson

86000

CHU la Miletrie, Poitiers

89169

Comprehensive Cancer Centers Of Nevada, Las Vegas

90404

UCLA Hematology Oncology, Santa Monica

91010

City of Hope Comprehensive Cancer Center, Duarte

06510

Yale Cancer Center, New Haven

20016-2633

Sibley Memorial Hospital, Washington D.C.

Unknown

"Severance Hospital , Yonsei University Health System"

"Asan Medical Center , University of Ulsan College of Medicine"

Kyungpook National University Chilgok Hospital, Seoul

BT9 7AB

Belfast City Hospital, Belfast

AB25 2ZN

Aberdeen Royal Infirmary, Aberdeen

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Gilead Sciences

INDUSTRY

lead

Arcus Biosciences, Inc.

INDUSTRY