Folfox+Irinotecan+Chemort In Esophageal Cancer

"A cycle will be two weeks (14 days) long, with FOLFOX/ nal-IRI administered on days 1-3.~The order of FOLFOX/ nal-IRI administration is as follows:~* 1\) Liposomal Irinotecan free base via IV, predetermined dosage per protocol~* 2\) Oxaliplatin via IV, predetermined dosage per protocol~* 3\) Leucovorin via IV, predetermined dosage per protocol~* 4\) 5-Fluorouracil via IV, predetermined dosage per protocol"

Paclitaxel and Carboplatin will be given concurrently with radiation therapy weekly (+/- 1 day).

Paclitaxel and Carboplatin will be given concurrently with radiation therapy weekly (+/- 1 day).

Chemoradiation with proton or photon radiation therapy concurrent with weekly Paclitaxel and Carboplatin for 5 weeks