A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion

EARLY_PHASE1RecruitingINTERVENTIONAL
Enrollment

15

Participants

Timeline

Start Date

April 8, 2021

Primary Completion Date

December 1, 2025

Study Completion Date

December 1, 2025

Conditions
High Grade GliomaDiffuse Intrinsic Pontine Glioma
Interventions
DRUG

Larotrectinib

"1. Larotrectinib monotherapy x2 cycles followed by disease evaluation~2. Larotrectinib with or without chemotherapy backbone"

PROCEDURE

Larotrectinib surgical

"1. Surgical cohort: Larotrectinib x 3-5 days prior to definitive surgery followed by Larotrectinib monotherapy x2 cycles followed by disease evaluation~2. Larotrectinib with or without chemotherapy backbone"

Trial Locations (20)

2031

RECRUITING

Sydney Children's Hospital, Randwick

4101

RECRUITING

Queensland Children's Hospital, South Brisbane

6000

RECRUITING

Perth Children's Hospital, Perth

19104

RECRUITING

Children's Hospital of Philadelphia, Philadelphia

20010

RECRUITING

Children's National Medical Center, Washington D.C.

27708

RECRUITING

Duke University Health System, Durham

43235

RECRUITING

Nationwide Children's Hospital, Columbus

45229

RECRUITING

Cincinnati Children's Hospital Medical Center, Cincinnati

60611

NOT_YET_RECRUITING

Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago

69120

RECRUITING

Hopp Children's Cancer Center at NCT Heidelberg (KiTZ), Heidelberg

77030

RECRUITING

Texas Children's Hospital, Houston

80045

RECRUITING

Children's Hospital Colorado, Aurora

98105

RECRUITING

Seattle Children's Hospital, Seattle

02215

RECRUITING

Dana-Farber Cancer Institute, Boston

M5G1X8

RECRUITING

The Hospital for Sick Children (SickKids), Toronto

H4A3J1

RECRUITING

Montreal Children's Hospital, Montreal

Unknown

RECRUITING

University Medical Center Augsburg, Augsburg

RECRUITING

University Hospital Berlin, Berlin

RECRUITING

University Hospital Koln, Cologne

RECRUITING

University Medical Center Gottingen, Göttingen

All Listed Sponsors
lead

Nationwide Children's Hospital

OTHER