Study Evaluating mCRPC Treatment Using PSMA [Lu-177]-PNT2002 Therapy After Second-line Hormonal Treatment

PHASE3Active, not recruitingINTERVENTIONAL
Enrollment

415

Participants

Timeline

Start Date

February 25, 2021

Primary Completion Date

November 1, 2023

Study Completion Date

March 31, 2028

Conditions
Metastatic Castration-Resistant Prostate Cancer
Interventions
DRUG

[Lu-177]-PNT2002

Participants randomized to Arm A will receive 6.8 GBq (±10%) of \[Lu-177\]-PNT2002 every 8 weeks for 4 cycles

DRUG

Abiraterone

Abiraterone (1000 mg orally qd with: 5 mg bid prednisone or 0.5 mg qd dexamethasone)

DRUG

Enzalutamide

Enzalutamide (160 mg orally qd)

Trial Locations (54)

10065

New York Presbyterian Hospital/Weill Cornell Medical Center, New York

13385

La Timone Hospital, Nuclear Medicine Department, Marseille

19104

Perelman Center for Advanced Medicine, Philadelphia

19111

Fox Chase Cancer Center, Philadelphia

21201

University of Maryland Greenebaum Cancer Center, Baltimore

21204

Chesapeake Urology Associates (CUA) P.A., Towson

29572

Carolina Urologic Research Center, Myrtle Beach

33612

H. Lee Moffitt Cancer Center & Research Institute, Tampa

34298

Montpellier Cancer Institute, Department of Nuclear Medicine, Montpellier

37232

Vanderbilt-Ingram Cancer Center, Nashville

40536

University of Kentucky Chandler Medical Center, Lexington

41345

Sahlgrenska University Hospital, Gothenburg

45212

Tri-State Urologic Services, Cincinnati

45409

Greater Dayton Cancer Center, Kettering

48109

University of Michigan Hospitals, Ann Arbor

48201

Karmanos Cancer Center, Detroit

52242

University of Iowa Hospitals and Clinics, Iowa City

59037

Claude Huriez Hospital, Lille

63011

Center Jean Perrin, Department of Medical Oncology, Clermont-Ferrand

63106

VA St. Louis Health Care System, St Louis

63110

Saint Louis University Hospital, St Louis

Washington University School of Medicine, St Louis

68130

Urology Cancer Center, PC, Omaha

69373

Leon Berard Center, Lyon

70112

Tulane University Medical Center, New Orleans

75020

Tenon Hospital, Department of Medical Oncology, Paris

75216

Dallas VA Medical Center, Nuclear Medicine Service, Dallas

75390

UT Southwestern Medical Center, Dallas

77402

Excel Diagnostics & Nuclear Oncology Center, Houston

80045

University of Colorado Hospital, Aurora

85704

Arizona Institute of Urology (AIU) - Tucson, Tucson

87109

New Mexico Oncology Hematology Consultants Ltd., New Mexico Cancer Center, Albuquerque

90048

Cedars-Sinai Medical Center, Samuel Oschin Comprehensive Cancer Institute, Los Angeles

90073

VA Greater Los Angeles Healthcare System, Los Angeles

90095

University of California Los Angeles, Nuclear Medicine Clinic, Los Angeles

92663

Hoag Memorial Hospital Presbyterian, Newport Beach

92868

UC Irvine Chao Family Comprehensive Cancer Center, Orange

94305

Stanford Cancer Institute, Palo Alto

98104

Swedish Cancer Institute Research, Seattle

08816

Astera Cancer Care, East Brunswick

V5Z 4E6

BC Cancer - Vancouver, Vancouver

B3H 2Y9

Nova Scotia Health Authority, Halifax

N6A 5W9

London Health Sciences Center - Victoria Hospital, London

M4N 3M5

Sunnybrook Research Institute, Odette Cancer Center, Toronto

M5G 2M9

Princess Margaret Cancer Centre, Toronto

H2X 3E4

CHUM - University Hospital of Montreal, Montreal

H3T 1E2

Jewish General Hospital, Montreal

G1R 2J6

CHU of Quebec - Laval University, Québec

Unknown

St. Antonius Hospital, Nieuwegein

Radboud University Medical Center (Radboudumc), Nijmegen

Norrlands University Hospital, Department of Radiation Sciences, Oncology, Umeå

Charing Cross Hospital, Department of Medical Oncology, London

Royal Marsden NHS Foundation Trust - Institute of Cancer Research, Sutton

3015 GD

Erasmus University Medical Center Rotterdam, Rotterdam

All Listed Sponsors
lead

POINT Biopharma, a wholly owned subsidiary of Eli Lilly and Company

INDUSTRY

NCT04647526 - Study Evaluating mCRPC Treatment Using PSMA [Lu-177]-PNT2002 Therapy After Second-line Hormonal Treatment | Biotech Hunter | Biotech Hunter