Trastuzumab Deruxtecan in Participants With HER2-mutated Metastatic Non-small Cell Lung Cancer (NSCLC)

PHASE2CompletedINTERVENTIONAL
Enrollment

152

Participants

Timeline

Start Date

March 19, 2021

Primary Completion Date

December 23, 2022

Study Completion Date

August 23, 2024

Conditions
Non-Small Cell Lung Cancer
Interventions
DRUG

Trastuzumab deruxtecan

Trastuzumab deruxtecan 100 mg will be provided as a sterile lyophilized powder and reconstituted with 5 mL water for injection (final concentration 20 mg/mL \[ie, 100 mg/5 mL\]). The study drug will be administered as an intravenous (IV) infusion over 30 to 90 min Q3W ± 2 days. The initial dose of study drug will be infused for 90 ± 10 min.

Trial Locations (50)

333

Chang Gung Memorial Hospital CGMH - LinKou Branch, Taoyuan District

704

National Cheng Kung University Hospital NCKUH, Tainan City

3080

Asan Medical Center, Seoul

4102

Princess Alexandra Hospital, Woolloongabba

6008

St John of God Subiaco Hospital, Subiaco

6351

Samsung Medical Center, Seoul

10002

National Taiwan University Hospital, Taipei

10043

Azienda Ospedaliero-Universitaria San Luigi Gonzaga, Orbassano

11111

National Hospital Organization Kyushu Cancer Center, Fukuoka

13015

Assistance Publique Hopitaux de Marseille AP-HM, Hopital NORD, Marseille

20089

Humanitas Cancer Center Istituto Clinico Humanitas, Rozzano

20141

IRCCS Istituto Europeo di Oncologia, Milan

22031

Virgina Cancer Specialists, Fairfax

28027

Clinica Universidad de Navarra, Madrid

28040

Hospital Universitario Fundacion Jimenez Diaz, Madrid

28041

Hospital 12 de Octubre, Madrid

28644

Chungbuk National University Hospital, Jungbuk

31008

Clinica Univ. de Navarra - P, Pamplona

31059

CHU toulouse - hôpital Larrey, Toulouse

32803

AdventHealth Orlando, Orlando

33612

H. Lee Moffitt Cancer Center & Research Institute, Tampa

35000

Hopital Pontchaillou, Rennes

37203

Sarah Cannon Research Institute, Nashville

40241

Norton Cancer Institute, Louisville

40705

Chung Shan Medical University Hospital, Taichung

Taichung Veterans General Hospital, Taichung

41124

SC Oncologia, AOU Policlinico Modena, Modena

44800

CHU Nantes, Saint-Herblain

46026

Hospital Universitari i Politècnic La Fe, Valencia

48202

Henry Ford Cancer Institute/Henry Ford Hospital, Detroit

University of Michigan, Detroit

55100

Ospedale San Luca, Lucca

63110

Washington University School of Medicine, St Louis

69008

Centre Leon Berard, Lyon

80045

University of Colorado Denver - Anschutz Medical Campus, Aurora

80131

Istituto Nazionale Tumori Fondazione G. Pascale di Napoli Strutturadi Oncologia, Napoli

94800

Gustav Roussy, Villejuif

02114

Massachusetts General Hospital (MGH) - Hematology/Oncology, Boston

02215

Dana-Farber Cancer Institute, Boston

M5G0A3

University Health Network, Toronto

464-8681

Aichi Cancer Center Hospital, Chikusa

104-0045

National Cancer Central Hospital, Chūōku

277-0882

National Cancer Center Hospital East, Kashiwa

700-8558

Okayama University Hospital, Okayama

589-8511

Kindai University Hospital, Ōsaka-sayama

1066CX

Netherlands Cancer Institute, Amsterdam

3015 GD

Erasmus MC, Rotterdam

463-707

Seoul National University Bundang Hospital, Seongnam

03080

Seoul National University Hospital, Seoul

08023

Hospital Universitario Vall d'Hebron, Barcelona

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

AstraZeneca

INDUSTRY

lead

Daiichi Sankyo

INDUSTRY