80
Participants
Start Date
March 17, 2021
Primary Completion Date
October 30, 2025
Study Completion Date
December 31, 2025
Atropine challenge
Atropine challenge. After baseline FLIP, subjects will be administered 15 mcg/kg of intravenous atropine. Two minutes after administration, FLIP will be repeated.
Esophageal muscle biopsy
Esophageal muscle biopsy. During standard-of-care Heller myotomy or per-oral endoscopic myotomy, 5mm of lower esophageal sphincter and distal esophageal circular muscle will be collected via biopsy forceps.
RECRUITING
Emory University Hospital, Atlanta
RECRUITING
Emory Saint Joseph's Hospital, Atlanta
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
NIH
Emory University
OTHER