NCT04639050View on ClinicalTrials.gov

Brainshuttle AD: A Multiple Ascending Dose Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7126209 Following Intravenous Infusion in Participants With Prodromal or Mild to Moderate Alzheimer's Disease

PHASE1/PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

285

Participants

Timeline

Start Date

March 15, 2021

Primary Completion Date

June 30, 2030

Study Completion Date

June 30, 2030

Conditions
Alzheimers Disease
Interventions
DRUG

RO7126209

RO7126209 will be administered intravenously as specified in each treatment arm.

DRUG

Placebo

RO7126209-matching placebo will be administered intravenously as specified in each treatment arm.

Trial Locations (44)

3004

Alfred Hospital, Melbourne

3081

Heidelberg Repatriation Hospital, Heidelberg West

8195

Hospital General De Catalunya, Sant Cugat del Vallès

19001

Abington Neurological Associates, Abington

20014

Policlínica Guipuzcoa, Donostia / San Sebastian

22332

Inha University Hospital, Incheon

28041

Hospital Universitario 12 de Octubre, Madrid

30501

Center for Advanced Research & Education, Gainesville

31909

Columbus Memory Center, Columbus

32159

K2 Medical Research - The Villages, Lady Lake

32162

Charter Research - Lady Lake/The Villages, The Villages

32751

K2 Medical Research, LLC, Maitland

32789

Conquest Research, LLC, Winter Park

32803

Charter Research - Winter Park/Orlando, Orlando

32804

Advent Health Orlando, Orlando

33135

Optimus U Corp, Miami

33414

Alzheimer?s Research and Treatment Center, Wellington

33462

JEM Research LLC, Atlantis

34711

K2 Medical Research-Winter Garden, Clermont

34997

Alzheimer's Research and Treatment Center, Stuart

46017

Hospital Universitario Dr. Peset, Valencia

46026

Hospital Universitario la Fe, Valencia

48334

Quest Research Institute, Farmington Hills

75231

Kerwin Research Center, LLC, Dallas

97210

Summit Research Network Inc., Portland

8330034

Centro de Investigación Clínica UC-CICUC, Santiago

8380456

Hospital Clinico Univ de Chile, Santiago

V6V 2L1

Richmond Clinical Trials, Richmond

M3B 2S7

Toronto Memory Program, Toronto

231-8682

Yokohama City Minato Red Cross Hospital, Kanagawa

600-8558

Koseikai Takeda Hospital, Kyoto

616-8255

National Hospital Organization Utano National Hospital, Kyoto

160-8582

Keio University Hospital, Tokyo

173-0015

Tokyo Metropolitan Geriatric Hospital, Tokyo

190-8531

Federation of National Public Service Personnel Mutual Aid Associations Tachikawa Hospital, Tokyo

70-111

Osrodek Badan Klinicznych Euromedis, Szczecin

53-659

NZOZ WCA, Wroc?aw

06351

Samsung Medical Center, Seoul

08028

Fundación ACE, Barcelona

08036

Hospital Clinic i Provincial, Barcelona

B16 8QQ

Re-Cognition, Birmingham

BS32 4SY

Recognition Health Bristol, Bristol

W1G 9JF

RE:Cognition Health, London

WC1N 3BG

UCL Institute of Neurology, London

All Listed Sponsors
lead

Hoffmann-La Roche

INDUSTRY