Pembrolizumab as Neoadjuvant Therapy for Resectable Stage IA3 to IIA Non-Small Cell Lung Cancer (NSCLC)

PHASE2RecruitingINTERVENTIONAL
Enrollment

44

Participants

Timeline

Start Date

August 28, 2022

Primary Completion Date

August 27, 2025

Study Completion Date

December 27, 2025

Conditions
Lung Cancer, Nonsmall Cell
Interventions
DRUG

Pembrolizumab

Neoadjuvant pembrolizumab 200 mg IV every 3 weeks, given on cycle day 1. Adjuvant pembrolizumab 400 mg IV every 6 weeks, given on cycle day 1.

DRUG

Carboplatin

Carboplatin AUC 6 IV (maximum dose: 900 mg) for squamous cell carcinoma, and AUC 5 IV (maximum dose: 750 mg) for non-squamous cell carcinoma, every 3 weeks, given on cycle day 1.

DRUG

Paclitaxel

Paclitaxel 200 mg/m2 IV every 3 weeks, given on cycle day 1. Only given to participants with squamous cell carcinoma.

DRUG

Pemetrexed

Pemetrexed 500 mg/m2 every 3 weeks, given on cycle day 1. Only given to participants with non-squamous cell carcinoma.

Trial Locations (1)

H4A3J1

RECRUITING

McGill University Health Center, Montreal

All Listed Sponsors
lead

McGill University Health Centre/Research Institute of the McGill University Health Centre

OTHER