Doravirine for Obese Persons on Integrase Inhibitors and Tenofovir Alafenamide

PHASE4CompletedINTERVENTIONAL
Enrollment

147

Participants

Timeline

Start Date

July 27, 2021

Primary Completion Date

October 18, 2024

Study Completion Date

October 18, 2024

Conditions
HIV Infections
Interventions
DRUG

Doravirine 100 Mg

Participants received a 100 mg tablet by mouth daily with or without food.

DRUG

Integrase strand transfer inhibitors

INSTIs were acquired through the standard of care locally.

DRUG

Tenofovir alafenamide/emtricitabine

NRTIs (TAF/FTC) were acquired through the standard of care locally.

DRUG

tenofovir disproxil fumarate/emtricitabine

NRTIs (TDF/FTC) were acquired through the standard of care locally.

Trial Locations (27)

10010

Weill Cornell Chelsea CRS (7804), New York

10032

Columbia Physicians and Surgeons (P&S) CRS (30329), New York

10065

Weill Cornell Upton CRS (7803), New York

14642

University of Rochester Adult HIV Therapeutic Strategies Network CRS (31787), Rochester

19104

Penn Therapeutics CRS (6201), Philadelphia

20005

Whitman-Walker Institute, Inc. CRS (31791), Washington D.C.

21205

Johns Hopkins University CRS (201), Baltimore

27401

Greensboro CRS (3203), Greensboro

27514

Chapel Hill CRS (3201), Chapel Hill

30308

The Ponce de Leon Center CRS (5802), Atlanta

35294

Alabama CRS (31788), Birmingham

37204

Vanderbilt Therapeutics (VT) CRS (3652), Nashville

43210

Ohio State University CRS (2301), Columbus

44106

Case CRS (2501), Cleveland

45267

Cincinnati CRS (2401), Cincinnati

60611

Northwestern University CRS (2701), Chicago

63110

Washington University Therapeutics (WT) CRS (2101), St Louis

77030

Houston AIDS Research Team CRS (31473), Houston

80045

University of Colorado Hospital CRS (6101), Aurora

90095

UCLA CARE Center CRS (601), Los Angeles

90502

Harbor-UCLA CRS (603), Torrance

92103

UCSD Antiviral Research Center CRS (701), San Diego

94110

Ucsf Hiv/Aids Crs (801), San Francisco

98104

University of Washington Positive Research CRS (1401), Seattle

02114

Massachusetts General Hospital (MGH) CRS (101), Boston

02115

Brigham and Women's Hosp. ACTG CRS (107), Boston

07103

New Jersey Medical School Clinical Research Center CRS (31786), Newark

All Listed Sponsors
collaborator

National Institute of Allergy and Infectious Diseases (NIAID)

NIH

lead

Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections

NETWORK

NCT04636437 - Doravirine for Obese Persons on Integrase Inhibitors and Tenofovir Alafenamide | Biotech Hunter | Biotech Hunter