Regeneration in Cervical Degenerative Myelopathy

PHASE3RecruitingINTERVENTIONAL
Enrollment

400

Participants

Timeline

Start Date

December 22, 2021

Primary Completion Date

September 1, 2026

Study Completion Date

September 1, 2026

Conditions
MyelopathySpinal Cord Diseases
Interventions
DRUG

Ibudilast

Increasing dose of ibudilast from 60mg/6 capsules per day to 100mg/10 capsules per day to be started up to 10 weeks prior to surgery. Treatment will continue up to 24 weeks after surgery. Maximum treatment period will be of 34 weeks.

PROCEDURE

Cervical decompressive surgery

Surgical decompression of degenerate cervical myelopathy

DRUG

Matching placebo

Increasing dose of matching placebo from 6 capsules per day to 10 capsules per day to be started up to 10 weeks prior to surgery. Treatment will continue up to 24 weeks after surgery. Maximum treatment period will be of 34 weeks.

Trial Locations (1)

CB20QQ

RECRUITING

Addenbrooke's Hospital, Cambridge

All Listed Sponsors
lead

Cambridge University Hospitals NHS Foundation Trust

OTHER