NKX101, Intravenous Allogeneic CAR NK Cells, in Adults With AML or MDS

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

61

Participants

Timeline

Start Date

September 21, 2020

Primary Completion Date

October 2, 2024

Study Completion Date

July 31, 2039

Conditions
Relapsed/Refractory AMLAML, AdultMDSRefractory Myelodysplastic Syndromes
Interventions
BIOLOGICAL

NKX101 - CAR NK cell therapy

NKX101 is an investigational allogeneic CAR NK product targeting NKG2D ligands on cancer cells. Part 2 will use the maximum tolerated dose (MTD) or recommended Phase 2 dose (RP2D) of NKX101 as determined in Part 1.

Trial Locations (8)

30322

Winship Cancer Institute, Emory University, Atlanta

32224

Mayo Clinic Florida, Jacksonville

37203

Sarah Cannon at TriStar Bone Marrow Transplant Center, Nashville

44195

The Cleveland Clinic - Taussig Cancer Institute, Cleveland

60637

University of Chicago Medical Center, Chicago

77030

MD Anderson Cancer Center, University of Texas, Houston

78229

Methodist Healthcare System of San Antonio, San Antonio

80218

Colorado Blood Cancer Institute, Denver

All Listed Sponsors
lead

Nkarta, Inc.

INDUSTRY

NCT04623944 - NKX101, Intravenous Allogeneic CAR NK Cells, in Adults With AML or MDS | Biotech Hunter | Biotech Hunter