Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia. A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation.

PHASE2/PHASE3CompletedINTERVENTIONAL
Enrollment

194

Participants

Timeline

Start Date

December 31, 2012

Primary Completion Date

November 22, 2019

Study Completion Date

March 6, 2020

Conditions
Alzheimers DiseaseDementiaAlzheimers Disease, Familial
Interventions
DRUG

Gantenerumab

Subcutaneously every 4 weeks at escalating doses

DRUG

Solanezumab

Intravenous infusion every 4 weeks at escalating doses

DRUG

Matching Placebo (Gantenerumab)

Subcutaneous injection of placebo every 4 weeks

DRUG

Matching Placebo (Solanezumab)

Intravenous infusion of placebo every 4 weeks

Trial Locations (25)

2031

Neuroscience Research Australia, Randwick

3010

Mental Health Research Institute, Melbourne

6009

The McCuster Foundation of Alzheimer's Disease Research, Nedlands

8036

Hospital Clínic I Provincial de Barcelona, Barcelona

10032

Columbia University, New York

15213

University of Pittsburgh, Pittsburgh

30329

Emory University, Atlanta

31059

CHU de Toulouse - Hôpital Purpan, Toulouse

35294

University of Alabama in Birmingham, Birmingham

46202

Indiana University School of Medicine, Indianapolis

59037

Hopital Roger Salengro - CHU Lille, Lille

63110

Washington University in St. Louis, St Louis

69677

Groupe Hospitalier Pitie-Salpetriere, Paris

Hopital Neurologique Pierre Wertheimer, Bron

76031

CHU de Rouen - Hôpital Charles Nicolle, Rouen

92037

University of California San Diego Medical Center, La Jolla

98195

University of Washington, Seattle

06510

Yale University School of Medicine, New Haven

02096

Butler Hospital, Providence

V6T 2B5

UBC Hospital, Vancouver

M4N 3M5

Sunnybrook Health Sciences Centre, Toronto

H4H 1R3

McGill Center for Studies in Aging, Verdun

DUBLIN 4

St Vincent's University Hospital, Dublin

00936

University of Puerto Rico, School of Medicine, San Juan

WC1B 3BG

The National Hospital for Neurology and Neurosurgery, London

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Eli Lilly and Company

INDUSTRY

collaborator

Hoffmann-La Roche

INDUSTRY

collaborator

Alzheimer's Association

OTHER

collaborator

National Institute on Aging (NIA)

NIH

collaborator

Avid Radiopharmaceuticals

INDUSTRY

collaborator

Accelerating Medicines Partnership (AMP)

OTHER

lead

Washington University School of Medicine

OTHER