Phase II Study of the Use of Neoadjuvant Cabazitaxel With Hormonal Treatment in Patients Operable Prostate Cancer, Assess the Efficacy and Toxicity of Cabazitaxel, and Explore Potential Predictive and Prognostic Markers of Clinical Outcome

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

120

Participants

Timeline

Start Date

January 15, 2021

Primary Completion Date

November 2, 2025

Study Completion Date

May 2, 2026

Conditions
Prostate Cancer
Interventions
DRUG

Cabazitaxel

"Patients will receive Cabazitaxel 25 mg/m2 \* intravenously over one hour every 21 days (on Day 1 of each cycle). Treatment will be continued for 4 cycles unless disease progression, unacceptable toxicity or patient request. These patients will have surgery (radical prostatectomy) 4-86 weeks following treatment.~\*Cabazitaxel dose should be capped at 50mg (BSA=2)"

All Listed Sponsors
collaborator

University of Liverpool

OTHER

lead

The Clatterbridge Cancer Centre NHS Foundation Trust

OTHER