Ketone Ester Intervention in Alcohol Use Disorder

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

April 5, 2021

Primary Completion Date

January 31, 2026

Study Completion Date

December 31, 2026

Conditions
Alcohol DrinkingAlcohol Use Disorder
Interventions
DIETARY_SUPPLEMENT

"Ketone Ester (R)-3-hydroxybutyl (R)-3-hydroxybutyrate"

nutritional ketone ester

DRUG

Isocaloric dextrose placebo

Drink indistinguishable from ketone ester

OTHER

Alcohol drinks

drink an alcohol priming dose to produce a 0.03 g/dl breath alcohol concentration (BrAC) followed by a choice paradigm in which subjects receive 2 trays of 4 min-drinks each beverages Each min-drink would achieve 0.015 g/ld BrAC over a 1 hour period to achieve a max 0.1 g/dl BrAC.

Trial Locations (1)

19104

RECRUITING

University of Pennsylvania Center for Studies of Addiction, Philadelphia

All Listed Sponsors
collaborator

National Institute on Alcohol Abuse and Alcoholism (NIAAA)

NIH

lead

University of Pennsylvania

OTHER