Novel Pulmonary Imaging of Lung Structure and Function in E-cigarette Smokers

RecruitingOBSERVATIONAL
Enrollment

150

Participants

Timeline

Start Date

January 17, 2023

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2027

Conditions
E Cigarette Use
Interventions
DIAGNOSTIC_TEST

Hyperpolarized Xenon-129 MRI of the lungs

Participants will be imaged using MRI using hyperpolarized xenon-129 gas as a contrast gas

DIAGNOSTIC_TEST

Computed Tomography (CT)

Participants will undergo a CT scan of the thoracic cavity

DIAGNOSTIC_TEST

Pulmonary Function Tests (PFT)

Participants will have their lung function evaluated using PFT

DIAGNOSTIC_TEST

Cardiopulmonary exercise testing (CPET)

Participants will perform cardiopulmonary exercise testing as a measure of exercise capacity

DIAGNOSTIC_TEST

Sputum analysis

Participants will provide a sputum sample that will be analysed for eosinophils

DIAGNOSTIC_TEST

Blood analysis

Participants will have their blood drawn and analysed for eosinophil count.

OTHER

Questionnaires

Participants will complete questionnaires to assess activity related dyspnea, respiratory symptoms and health status impairment and respiratory related quality of life.

Trial Locations (1)

N6A 5B7

RECRUITING

Robarts Research Institute; The University of Western Ontario; London Health Sciences Centre, London

Sponsors
All Listed Sponsors
collaborator

London Health Sciences Centre

OTHER

lead

Western University, Canada

OTHER