Study of Pamiparib in Newly Diagnosed and rGBM

60mg administered orally BID for 4 days prior to surgical resection

200mg administered orally BID for 4 days prior to surgical resection

Patients in Phase 2 will receive 6-7 weeks of radiation therapy per standard of care

Arm A and Arm B participants after RT is completed, will receive pamiparib in combination with TMZ (newly diagnosed participants). Arm C participants will receive olaparib with TMZ.