Phase 1b Study of Dato-DXd in Combination With Immunotherapy With or Without Carboplatin in Advanced or Metastatic Non-Small Cell Lung Cancer

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

165

Participants

Timeline

Start Date

February 2, 2021

Primary Completion Date

April 30, 2026

Study Completion Date

April 30, 2026

Conditions
Advanced or Metastatic NSCLC
Interventions
DRUG

Datopotamab deruxtecan

Intravenous infusion every 3 weeks (Q3W) on Day 1 of each 21-day cycle

DRUG

Durvalumab

Intravenous infusion every 3 weeks (Q3W) on Day 1 of each 21-day cycle

DRUG

Carboplatin

Intravenous infusion Q3W on Day 1 or Day 2 of each 21-day cycle

DRUG

AZD2936

Intravenous infusion prior to Dato-DXd every 3 weeks (Q3W) on Day 1 prior to Dato-Dxd of each 21-day cycle

DRUG

MEDI5752

Intravenous infusion prior to Dato-DXd every 3 weeks (Q3W) on Day 1 prior to Dato-Dxd of each 21-day cycle

DRUG

AZD7789

Intravenous infusion prior to Dato-DXd every 3 weeks (Q3W) on Day 1 prior to Dato-Dxd of each 21-day cycle

Trial Locations (42)

100

Research Site, Taipei

110

Research Site, Taipei

300

Research Site, Hsinchu

704

Research Site, Tainan City

3500

Research Site, Hasselt

6200

Research Site, Ankara

8036

Research Site, Barcelona

8800

Research Site, Roeselare

10043

Research Site, Orbassano

11217

Research Site, Taipei

15005

Research Site, A Coruña

19111

Research Site, Philadelphia

22031

Research Site, Fairfax

28034

Research Site, Madrid

28046

Research Site, Madrid

28050

Research Site, Madrid

33081

Research Site, Aviano

34010

Research Site, Istanbul

35330

Research Site, Izmir

40705

Research Site, Taichung

41015

Research Site, Seville

44106

Research Site, Cleveland

47014

Research Site, Meldola

63110

Research Site, St Louis

75230

Research Site, Dallas

77030

Research Site, Houston

78229

Research Site, San Antonio

92093

Research Site, La Jolla

92705

Research Site, Santa Ana

07601

Research Site, Hackensack

00144

Research Site, Roma

135-8550

Research Site, Kōtoku

411-8777

Research Site, Sunto-gun

241-8515

Research Site, Yokohama

80-952

Research Site, Gdansk

93-338

Research Site, Lodz

20-090

Research Site, Lublin

02-781

Research Site, Warsaw

08916

Research Site, Badalona

00333

Research Site, Taoyuan District

01060

Research Site, Adana

06800

Research Site, Ankara

Sponsors

Lead Sponsor

Collaborators (1)

All Listed Sponsors
collaborator

Daiichi Sankyo

INDUSTRY

lead

AstraZeneca

INDUSTRY