Evaluate the Safety, Immunogenicity and Potential Efficacy of an rVSV-SARS-CoV-2-S Vaccine

PHASE1/PHASE2CompletedINTERVENTIONAL
Enrollment

843

Participants

Timeline

Start Date

October 28, 2020

Primary Completion Date

October 3, 2022

Study Completion Date

October 3, 2022

Conditions
Covid19
Interventions
BIOLOGICAL

IIBR-100, low dose (prime)

Single administration of IIBR-100 1\*10E5 pfu/ml

BIOLOGICAL

IIBR-100 medium dose (prime)

Single administration of IIBR-100 1\*10E6 pfu/ml

BIOLOGICAL

IIBR-100 high-dose (prime)

Single administration of IIBR-100 1\*10E7 pfu/ml

BIOLOGICAL

IIBR-100 low-dose (prime-boost)

Two administrations of IIBR-100 1\*10E5 pfu/ml, 28 days apart

OTHER

Saline Placebo (single)

Single administration of saline placebo

OTHER

Saline Placebo (double)

Two administrations of saline placebo, 28 days apart

BIOLOGICAL

IIBR-100 medium-dose (prime-boost)

Two administrations of IIBR-100 1\*10E6 pfu/ml, 28 days apart

BIOLOGICAL

IIBR-100 high-dose (prime-boost)

Two administrations of IIBR-100 1\*10E7 pfu/ml, 28 days apart

BIOLOGICAL

IIBR-100 top-dose (prime-boost)

Two administrations of IIBR-100 1\*10E8 pfu/ml, 28 days apart

Trial Locations (8)

52621

Sheba Medical Center Hospital- Tel Hashomer, Ramat Gan

91120

Hadassah Medical Center, Jerusalem

Unknown

Assuta - University Hospital, Ashdod

Barzilai MC, Ashkelon

Rambam MC, Haifa

Meir MC, Kfar Saba

Rabin MC, Petah Tikva

Sourasky MC, Tel Aviv

All Listed Sponsors
lead

Israel Institute for Biological Research (IIBR)

OTHER_GOV