Study of Selinexor in Combination With Backbone Treatments or Novel Therapies In Participants With Relapsed or Refractory (RR) Diffuse Large B-Cell Lymphoma (DLBCL)

PHASE1/PHASE2WithdrawnINTERVENTIONAL
0
Timeline

Start Date

November 18, 2020

Primary Completion Date

December 31, 2025

Study Completion Date

December 31, 2025

Conditions
Relapsed or Refractory Diffuse Large B-Cell Lymphoma
Interventions
DRUG

Selinexor

Dose: 40 mg (2 tablets of 20 mg), 60 mg (3 tablets of 20 mg), 80 mg (4 tablets of 20 mg)

DRUG

Rituximab

Dose: 375 mg/m\^2

DRUG

Bendamustine

Dose: 90 mg/m\^2

DRUG

Polatuzumab Vedotin

Dose: 1.8 mg/kg

DRUG

Ibrutinib

Dose: 420, 560 mg

DRUG

Lenalidomide

Dose: 20, 25 mg

DRUG

Tafasitamab

Dose: 12 mg/kg

DRUG

Venetoclax

Dose: 200, 400, 600, 800 mg

DRUG

Gemcitabine

Dose: 1000 mg/m\^2

DRUG

Oxaliplatin

Dose: 100 mg/m\^2

Trial Locations (18)

14263

Roswell Park Comprehensive Cancer Center, Buffalo

15232

UPMC Hillman Cancer Center, Pittsburgh

29605

US Oncology - Prisma Health, Greenville

48021

Karmanos Cancer Institute, Detroit

48109

University of Michigan Health System, Ann Arbor

50309

Mission Cancer + Blood, Des Moines

60153

Loyola University Medical Center, Maywood

68198

University of Nebraska Medical Center, Omaha

75390

University of Texas Southwestern, Dallas

77030

Baylor Clinic - Mcnair Center, Houston

78705

US Oncology - Texas Oncology Austin Midtown, Austin

80012

US Oncology - Rocky Mountain Cancer Center, Aurora

85724

University of Arizona, Tucson

92024

California Cancer Associates for Research and Excellence, Encinitas

92093

UC San Diego Moores Cancer Center, La Jolla

92868

University of California Irvine, Orange

97401

US Oncology - Oncology Associates of Oregon, Eugene

98684

US Oncology - Northwest Cancer Specialists, Vancouver

Sponsors
All Listed Sponsors
lead

Karyopharm Therapeutics Inc

INDUSTRY