A Study of Amivantamab Subcutaneous (SC) Administration for the Treatment of Advanced Solid Malignancies

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

192

Participants

Timeline

Start Date

November 10, 2020

Primary Completion Date

July 11, 2024

Study Completion Date

December 31, 2026

Conditions
Advanced Solid Malignancies
Interventions
DRUG

Ami-LC-MD

Participants will receive amivantamab admixed with rHuPH20 SC infusion.

DRUG

Ami-LC

Participants will receive amivantamab SC infusion.

DRUG

Ami-HC

Participants will receive amivantamab SC infusion.

DRUG

Ami-HC-CF

Participants will receive amivantamab co-formulated with rHuPH20 as SC infusion.

DRUG

Lazertinib

Participants will receive lazertinib orally as a film-coated tablet.

Trial Locations (12)

10016

Langone Health at NYC University, NYU School of Medicine, New York

13620

Seoul National University Bundang Hospital, Seongnam-si

28644

Chungbuk National University Hospital, Cheongju-si

37203

Sarah Cannon Research Institute, Nashville

46256

Community Health Network, Indianapolis

90048

Cedars Sinai Medical Center, West Hollywood

97213

Providence Portland Medical Center, Portland

M5G 2M9

University Health Network, Toronto

03722

Severance Hospital Yonsei University Health System, Seoul

06351

Samsung Medical Center, Seoul

M20 4BX

The Christie Nhs Foundation Trust, Manchester

SM2 5PT

Royal Marsden Hospital, Sutton

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY

NCT04606381 - A Study of Amivantamab Subcutaneous (SC) Administration for the Treatment of Advanced Solid Malignancies | Biotech Hunter | Biotech Hunter