Explosive Synchronization of Brain Network Activity in Chronic Pain

NARecruitingINTERVENTIONAL
Enrollment

150

Participants

Timeline

Start Date

November 13, 2020

Primary Completion Date

October 31, 2025

Study Completion Date

October 31, 2025

Conditions
FibromyalgiaHealthy Volunteers
Interventions
DIAGNOSTIC_TEST

EEG

EEG with QST (evoked Pain and Visual Stimulation Assessment)

DIAGNOSTIC_TEST

Neuroimaging EEG/fMRI (Aim 1)

This will be done to monitor areas of the brain that are involved in thinking and processing pain. The scanner stimulates the brain to send out signals that will be recorded and analyzed. Additionally, during the MRI the participants brain's electrical activity with will be measured with an EEG machine for part of the MRI. About halfway through the scan, participants will have the EEG equipment removed and then will return to the fMRI scanner for a few additional scans.

DEVICE

HD-tDCS treatments

HD-tDCS treatments (5 active and 5 sham)

DEVICE

Sham HD-tDCS treatments

HD-tDCS treatments (5 active and 5 sham)

DIAGNOSTIC_TEST

Neuroimaging EEG/fMRI (Aim 3)

This will be done to monitor areas of the brain that are involved in thinking and processing pain. The scanner stimulates the brain to send out signals that will be recorded and analyzed. Additionally, during the MRI the participants brain's electrical activity with will be measured with an EEG machine for part of the MRI. About halfway through the scan, participants will have the EEG equipment removed and then (for participants prior to January 2025) will return to the fMRI scanner for a few additional scans.

Trial Locations (1)

48109

RECRUITING

University of Michigan, Ann Arbor

All Listed Sponsors
collaborator

National Center for Complementary and Integrative Health (NCCIH)

NIH

lead

University of Michigan

OTHER