Pemetrexed, Cisplatin With Soft Tissue Sarcoma

PHASE2RecruitingINTERVENTIONAL
Enrollment

164

Participants

Timeline

Start Date

December 22, 2020

Primary Completion Date

November 1, 2027

Study Completion Date

November 1, 2027

Conditions
Sarcoma,Soft Tissue
Interventions
DRUG

pemetrexed+cisplatin

"Pemetrexed 500 mg/m2 (Day 1) and cisplatin 75 mg/m2 (Day 1) will be given via intravenous (IV) infusion. Each cycle consists of 21 days, and this combination therapy will be continued until Cycle 6. Starting from Cycle 7, pemetrexed alone will be administered every 3 weeks (Q3W) as IV infusion until disease progression.~Vitamin B12 1000 mcg intramuscular (IM) injection will be given within 14 days prior to the first dose of pemetrexed, every 9 weeks (on the same day as study treatment) thereafter, and then 21 days after the last dose of pemetrexed. Folic acid 1 mg will be administered daily starting from 14 days before the first dose of pemetrexed and continued until 21 days after the last dose of pemetrexed. Study treatment will be continued until PD, unacceptable AE, or decision to discontinue by subject or physician."

Trial Locations (1)

03722

RECRUITING

Severance Hospital, Seoul

All Listed Sponsors
lead

Yonsei University

OTHER