Real World Clinical Outcomes With Novel Modulator Therapy Combinations in People With CF (RECOVER)

PHASE4Active, not recruitingINTERVENTIONAL
Enrollment

237

Participants

Timeline

Start Date

September 3, 2020

Primary Completion Date

April 1, 2029

Study Completion Date

July 1, 2029

Conditions
Cystic FibrosisCystic Fibrosis Liver DiseaseCystic Fibrosis in ChildrenAdherence, MedicationCystic Fibrosis Gastrointestinal Disease
Interventions
DRUG

Kaftrio

The intervention is the same for both study groups. In addition to all the assessments in the standard arm, the advanced arm subjects will undergo spirometry controlled CT, nasal lavage and sputum sample collection.

Trial Locations (7)

Unknown

Children's Health Ireland at Crumlin, Dublin

Children's Health Ireland at Temple Street, Dublin

St. Vincent's University Hospital, Dublin

Children's Health Ireland at Tallaght, Tallaght

Royal Belfast Hospital for Sick Children, Belfast

Royal Brompton Hospital, London

V94 F858

University Hospital Limerick, Limerick

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Imperial College London

OTHER

collaborator

University College Dublin

OTHER

collaborator

University of Limerick

OTHER

collaborator

Cystic Fibrosis Registry of Ireland

OTHER

collaborator

Erasmus Medical Center

OTHER

collaborator

Medizinische Hochschule Brandenburg Theodor Fontane

OTHER

collaborator

Queen's University, Belfast

OTHER

collaborator

Teagasc

INDUSTRY

collaborator

The Hospital for Sick Children

OTHER

collaborator

St. James's Hospital, Ireland

OTHER

collaborator

Amsterdam UMC

OTHER

lead

Royal College of Surgeons, Ireland

OTHER